Functionalization of N,N-Dialkylferrocenesulfonamides toward Substituted Derivatives
Résumé
Despite the well-established pharmacological properties of aromatic sulfonamides and the interest of introducing ferrocene into drugs, ferrocene sulfonamides have scarcely been studied. General synthetic methods using lithium bases to perform sulfonamide-directed deprotolithiation or the "halogen dance" reaction are here reported for the functionalization of N,N-dialkylferrocenesulfonamides toward various polysubstituted derivatives. Postfunctionalization of the ferrocenyl iodides by cross-coupling and lithium/iodine exchange reactions were also considered. Finally, the ligand behavior of new ferrocene phosphines in palladium-catalyzed coupling reactions was studied, and the reaction outcomes are viewed in light of DFT calculations.
Domaines
Chimie de coordination
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Wen_et al_2021_Functionalization of N N-Dialkylferrocenesulfonamides_accepted.pdf (1.91 Mo)
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Wen_et al_2021_Functionalization of N N-Dialkylferrocenesulfonamides_suppl data.pdf (8.38 Mo)
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