CAR-T cells and BiTEs in solid tumors: challenges and perspectives - Université de Rennes Accéder directement au contenu
Article Dans Une Revue Journal of Hematology and Oncology Année : 2021

CAR-T cells and BiTEs in solid tumors: challenges and perspectives

Résumé

Chimeric antigen receptor (CAR)-modified T cells and BiTEs are both immunotherapies which redirect T cell specificity against a tumor-specific antigen through the use of antibody fragments. They demonstrated remarkable efficacy in B cell hematologic malignancies, thus paving the way for their development in solid tumors. Nonetheless, the use of such new drugs to treat solid tumors is not straightforward. So far, the results from early phase clinical trials are not as impressive as expected but many improvements are under way. In this review we present an overview of the clinical development of CAR-T cells and BiTEs targeting the main antigens expressed by solid tumors. We emphasize the most frequent hurdles encountered by either CAR-T cells or BiTEs, or both, and summarize the strategies that have been proposed to overcome these obstacles.
Fichier principal
Vignette du fichier
Edeline2021_Article_CAR-TCellsAndBiTEsInSolidTumor.pdf (984.07 Ko) Télécharger le fichier
Origine : Fichiers éditeurs autorisés sur une archive ouverte

Dates et versions

hal-03228682 , version 1 (18-05-2021)

Licence

Paternité

Identifiants

Citer

Julien Edeline, Roch Houot, Aurélien Marabelle, Marion Alcantara. CAR-T cells and BiTEs in solid tumors: challenges and perspectives. Journal of Hematology and Oncology, 2021, 14 (1), pp.65. ⟨10.1186/s13045-021-01067-5⟩. ⟨hal-03228682⟩
86 Consultations
54 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More