Lung cancer risk in painters: results from the SYNERGY pooled case-control study consortium - Université de Rennes Access content directly
Journal Articles Occupational and Environmental Medicine Year : 2021

Lung cancer risk in painters: results from the SYNERGY pooled case-control study consortium

1 CIRC - IARC - Centre International de Recherche contre le Cancer - International Agency for Research on Cancer
2 IRAS - Institute for Risk Assessment Sciences [Utrecht, The Netherlands]
3 IPA - Institute for Prevention and Occupational Medicine of the German Social Accident Insurance
4 ESPUM - Département de médecine sociale et préventive [ESPUM-Montréal]
5 CESP - Centre de recherche en épidémiologie et santé des populations
6 Irset - Institut de recherche en santé, environnement et travail
7 German Research Center for Environmental Health - Helmholtz Center München (GmbH)
8 Fondazione IRCCS Ca' Granda - Ospedale Maggiore Policlinico
9 NCI-NIH - National Cancer Institute [Bethesda]
10 Karolinska Institute
11 UNITO - Università degli studi di Torino = University of Turin
12 Ruhrlandklinik University Hospital
13 Leibniz Institute for Prevention Research and Epidemiology - BIPS
14 The Chinese University of Hong Kong [Hong Kong]
15 University of Oviedo
16 SBU - Stony Brook University [SUNY]
17 N.N. Blokhin National Medical Research Center of Oncology
18 Massey University
19 LSHTM - London School of Hygiene and Tropical Medicine
20 University of Liverpool
21 MCMCC - Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology
22 NIOM - Nofer Institute of Occupational Medicine
23 University of Toronto
24 Occupational Cancer Research Centre
25 First Faculty of Medicine Charles University [Prague]
26 MMCI - Masaryk Memorial Cancer Institute
27 Palacky University Olomouc
28 National Public Health Centre,
29 RAPH - Regional Authority of Public Health [Slovaquia]
30 INSP - National Institute of Public Health [Romania]
31 ASL - Azienda Sanitaria Locale [ROMA]
32 RIVM - National Institute for Public Health and the Environment [Bilthoven]
Nils Plato
  • Function : Author
Francesco Forastiere


Objectives We evaluated the risk of lung cancer associated with ever working as a painter, duration of employment and type of painter by histological subtype as well as joint effects with smoking, within the SYNERGY project. Methods Data were pooled from 16 participating case-control studies conducted internationally. Detailed individual occupational and smoking histories were available for 19 369 lung cancer cases (684 ever employed as painters) and 23 674 age-matched and sex-matched controls (532 painters). Multivariable unconditional logistic regression models were adjusted for age, sex, centre, cigarette pack-years, time-since-smoking cessation and lifetime work in other jobs that entailed exposure to lung carcinogens. Results Ever having worked as a painter was associated with an increased risk of lung cancer in men (OR 1.30; 95% CI 1.13 to 1.50). The association was strongest for construction and repair painters and the risk was elevated for all histological subtypes, although more evident for small cell and squamous cell lung cancer than for adenocarcinoma and large cell carcinoma. There was evidence of interaction on the additive scale between smoking and employment as a painter (relative excess risk due to interaction >0). Conclusions Our results by type/industry of painter may aid future identification of causative agents or exposure scenarios to develop evidence-based practices for reducing harmful exposures in painters.
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Dates and versions

hal-03203232 , version 1 (26-05-2021)


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Neela Guha, Liacine Bouaoun, Hans Kromhout, Roel Vermeulen, Thomas Bruening, et al.. Lung cancer risk in painters: results from the SYNERGY pooled case-control study consortium. Occupational and Environmental Medicine, 2021, 78 (4), pp.269-278. ⟨10.1136/oemed-2020-106770⟩. ⟨hal-03203232⟩
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