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Article Dans Une Revue European Respiratory Journal Année : 2020

Age of onset of rhinitis as a determinant of different rhinitis phenotypes

Résumé

Rhinitis is a heterogeneous disease. Age of onset of rhinitis as a determinant of the different phenotypes has not yet been explored. Our aim was to describe phenotypes of rhinitis accordi ng to age of onset in adults from Constances, a large French population-based cohort. The 2014 annual follow-up questionnaire included detailed and validated questions that have allowed us to define rhinitis and its different phenotypes. This questionnaire was sent to 26,737 adults and completed by 21,507. We included in this analysis 5,795 participants with current rhinitis, thus is who reported symptoms in the last 12 months, and informed about the age of onset. We categorized the age of onset of rhinitis as follows: < 16, [16-30[, [30-45[, [45-60[ and ≥ 60 years. The mean age of onset was 26.7 years, 24.3 years for allergie rhinitis (AR) and 34.5 years for non-allergie rhinitis (NAR). The later the age of onset, the number of participants reporting AR decreased while the number was quite constant for NAR. Self-reported triggers of symptoms varied depending on the age of onset (see Figure). Participants with a later age of onset, whether with AR or NAR, reported more persistent rhinitis and fewer severe symptoms. Beyond allergy, age of onset seems to be an essential characteristic of rhinitis. These findings may have epidemiological and clinical implications, especially given that the prevalence of rhinitis is high in the general population.
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Dates et versions

hal-03161883 , version 1 (08-03-2021)

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Marine Savouré, Jean Bousquet, Marie Zins, Marcel Goldberg, Bénédicte Jacquemin, et al.. Age of onset of rhinitis as a determinant of different rhinitis phenotypes. European Respiratory Journal, 2020, 56 (64s), pp.433. ⟨10.1183/13993003.congress-2020.433⟩. ⟨hal-03161883⟩
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