Cholangiocarcinoma 2020: the next horizon in mechanisms and management - Université de Rennes Accéder directement au contenu
Article Dans Une Revue Nature reviews. Gastroenterology & hepatology Année : 2020

Cholangiocarcinoma 2020: the next horizon in mechanisms and management

Angela Lamarca
Pedro M. Rodrigues
  • Fonction : Auteur
Lewis R. Roberts
  • Fonction : Auteur
Marco Marzioni
  • Fonction : Auteur
Laura Fouassier
Sumera Rizvi
  • Fonction : Auteur
Julie Heimbach
  • Fonction : Auteur
John Bridgewater
  • Fonction : Auteur
Gregory J. Gores
  • Fonction : Auteur

Résumé

Cholangiocarcinoma (CCA) includes a cluster of highly heterogeneous biliary malignant tumours that can arise at any point of the biliary tree. Their incidence is increasing globally, currently accounting for ~15% of all primary liver cancers and ~3% of gastrointestinal malignancies. The silent presentation of these tumours combined with their highly aggressive nature and refractoriness to chemotherapy contribute to their alarming mortality, representing ~2% of all cancer-related deaths worldwide yearly. The current diagnosis of CCA by non-invasive approaches is not accurate enough, and histological confirmation is necessary. Furthermore, the high heterogeneity of CCAs at the genomic, epigenetic and molecular levels severely compromises the efficacy of the available therapies. In the past decade, increasing efforts have been made to understand the complexity of these tumours and to develop new diagnostic tools and therapies that might help to improve patient outcomes. In this expert Consensus Statement, which is endorsed by the European Network for the Study of Cholangiocarcinoma, we aim to summarize and critically discuss the latest advances in CCA, mostly focusing on classification, cells of origin, genetic and epigenetic abnormalities, molecular alterations, biomarker discovery and treatments. Furthermore, the horizon of CCA for the next decade from 2020 onwards is highlighted.
Fichier principal
Vignette du fichier
s41575-020-0310-z.pdf (3.87 Mo) Télécharger le fichier
Origine : Publication financée par une institution

Dates et versions

hal-03106830 , version 1 (28-05-2021)

Identifiants

Citer

Jesus M. Banales, Jose J. G. Marin, Angela Lamarca, Pedro M. Rodrigues, Shahid A. Khan, et al.. Cholangiocarcinoma 2020: the next horizon in mechanisms and management. Nature reviews. Gastroenterology & hepatology, 2020, 17 (9), pp.557-588. ⟨10.1038/s41575-020-0310-z⟩. ⟨hal-03106830⟩
62 Consultations
63 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More