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Article Dans Une Revue Cellular Immunology Année : 2021

Effects of vitamin D on macrophages and myeloid-derived suppressor cells (MDSCs) hyperinflammatory response in the lungs of COVID-19 patients

Résumé

Vitamin D regulates homeostasis, anti-microbial response, and inflammation. The vitamin D receptors are expressed in the macrophages and other immune cells, regulating the transcription of many different genes, including those coding the anti-microbial peptides. One of the most severe complications of the SARS-CoV-2 infection is the acute respiratory distress syndrome (ARDS) caused by the hyperinflammatory response (commonly called cytokine storm) of the lung macrophages. Studies showed that Vitamin D deficiency increases the severity of the ARDS in COVID-19 infection. We discuss here how the vitamin D supplementation may influence macrophage and myeloid-derived suppressor cells (MDSCs) inflammatory response, subdue the hyperinflammatory response, and lessen the ARDS in COVID-19 patients.
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Dates et versions

hal-03099319 , version 1 (25-01-2021)

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Malgorzata Kloc, Rafik M Ghobrial, Agnieszka Lipińska-Opałka, Agata Wawrzyniak, Robert Zdanowski, et al.. Effects of vitamin D on macrophages and myeloid-derived suppressor cells (MDSCs) hyperinflammatory response in the lungs of COVID-19 patients. Cellular Immunology, 2021, 360, pp.104259. ⟨10.1016/j.cellimm.2020.104259⟩. ⟨hal-03099319⟩
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