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Article Dans Une Revue Trends in Cell Biology Année : 2020

When Endoplasmic Reticulum Proteostasis Meets the DNA Damage Response

Résumé

Sustaining both proteome and genome integrity (GI) requires the integration of a wide range of mechanisms and signaling pathways. These comprise, in particular, the unfolded protein response (UPR) and the DNA damage response (DDR). These adaptive mechanisms take place respectively in the endoplasmic reticulum (ER) and in the nucleus. UPR and DDR alterations are associated with aging and with pathologies such as degenerative diseases, metabolic and inflammatory disorders, and cancer. We discuss the emerging signaling crosstalk between UPR stress sensors and the DDR, as well as their involvement in cancer biology.
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Dates et versions

hal-03004358 , version 1 (19-11-2020)

Identifiants

Citer

M. González-Quiroz, A. Blondel, A. Sagredo, C Hetz, E. Chevet, et al.. When Endoplasmic Reticulum Proteostasis Meets the DNA Damage Response. Trends in Cell Biology, 2020, 30 (11), pp.881-891. ⟨10.1016/j.tcb.2020.09.002⟩. ⟨hal-03004358⟩
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