Apoptotic mitochondrial dysfunction induced by benzo(a)pyrene in liver epithelial cells: role of p53 and pHi changes. - Université de Rennes Accéder directement au contenu
Article Dans Une Revue Annals of the New York Academy of Sciences Année : 2003

Apoptotic mitochondrial dysfunction induced by benzo(a)pyrene in liver epithelial cells: role of p53 and pHi changes.

Résumé

How pH(i) changes, more specifically alkalinization, affect the apoptotic cascade has yet to be determined. The aim of the present work was to test the involvement of mitochondria in the apoptotic cascade triggered by benzo(a)pyrene [B(a)P] and to determine the role of pH(i) changes and p53 relative to mitochondria. Our results indicate that B(a)P-induced apoptosis might rely upon a p53-dependent and a pH-sensitive mitochondrial dysfunction.
Fichier principal
Vignette du fichier
2003Huc-et-alNYAS_1.pdf (847.69 Ko) Télécharger le fichier
Origine : Fichiers produits par l'(les) auteur(s)
Loading...

Dates et versions

hal-02681880 , version 1 (31-05-2020)

Identifiants

Citer

Laurence Huc, David Gilot, Claire Gardyn, Mary Rissel, Marie-Thérèse Dimanche-Boitrel, et al.. Apoptotic mitochondrial dysfunction induced by benzo(a)pyrene in liver epithelial cells: role of p53 and pHi changes.. Annals of the New York Academy of Sciences, 2003, 1010, pp.167-70. ⟨hal-02681880⟩
34 Consultations
29 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More