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Article Dans Une Revue Nucleic Acids Research Année : 2001

The complete genome sequence of the murine respiratory pathogen Mycoplasma pulmonis

Résumé

Mycoplasma pulmonis is a wall-less eubacterium belonging to the Mollicutes (trivial name, mycoplasmas) and responsible for murine respiratory diseases. The genome of strain UAB CTIP is composed of a single circular 963 879 bp chromosome with a G + C content of 26.6 mol%, i.e. the lowest reported among bacteria, Ureaplasma urealyticum apart. This genome contains 782 putative coding sequences (CDSs) covering 91.4% of its length and a function could be assigned to 486 CDSs whilst 92 matched the gene sequences of hypothetical proteins, leaving 204 CDSs without significant database match. The genome contains a single set of rRNA genes and only 29 tRNAs genes. The replication origin oriC was localized by sequence analysis and by using the G + C skew method. Sequence polymorphisms within stretches of repeated nucleotides generate phase-variable protein antigens whilst a recombinase gene is likely to catalyse the site-specific DNA inversions in major M.pulmonis surface antigens. Furthermore, a hemolysin, secreted nucleases and a glyco-protease are predicted virulence factors. Surprisingly, several of the genes previously reported to be essential for a self-replicating minimal cell are missing in the M.pulmonis genome although this one is larger than the other mycoplasma genomes fully sequenced until now.
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hal-02679458 , version 1 (31-05-2020)

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Paternité - Pas d'utilisation commerciale

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Isabelle Chambaud, Roland Heilig, Stephane Ferris, Valérie Barbe, Delphine Samson, et al.. The complete genome sequence of the murine respiratory pathogen Mycoplasma pulmonis. Nucleic Acids Research, 2001, 29 (10), pp.2145-2153. ⟨10.1093/nar/29.10.2145⟩. ⟨hal-02679458⟩
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