Gene expression levels influence amino acid usage and evolutionary rates in endosymbiotic bacteria - Université de Rennes Accéder directement au contenu
Article Dans Une Revue Gene Année : 2005

Gene expression levels influence amino acid usage and evolutionary rates in endosymbiotic bacteria

Résumé

Most endosymbiotic bacteria have extremely reduced genomes, accelerated evolutionary rates, and strong AT base compositional bias thought to reflect reduced efficacy of selection and increased mutational pressure. Here, we present a comparative study of evolutionary forces shaping five fully sequenced bacterial endosymbionts of insects. The results of this study were three-fold: (i) Stronger conservation of high expression genes at not just nonsynonymous, but also synonymous, sites. (ii) Variation in amino acid usage strongly correlates with GC content and expression level of genes. This pattern is largely explained by greater conservation of high expression genes, leading to their higher GC content. However, we also found indication of selection favoring GC-rich amino acids that contrasts with former studies. (iii) Although the specific nutritional requirements of the insect host are known to affect gene content of endosymbionts, we found no detectable influence on substitu! tion rates, amino acid usage, or codon usage of bacterial genes involved in host nutrition.

Mots clés

Domaines

Génétique

Dates et versions

hal-02677829 , version 1 (31-05-2020)

Identifiants

Citer

J. Schaber, Claude Rispe, J. Wernegreen, A. Buness, François F. Delmotte, et al.. Gene expression levels influence amino acid usage and evolutionary rates in endosymbiotic bacteria. Gene, 2005, 352, pp.109-117. ⟨10.1016/j.gene.2005.04.003⟩. ⟨hal-02677829⟩
5 Consultations
0 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More