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Article Dans Une Revue Veterinary Pathology Année : 2011

Colorectal Hamartomatous Polyposis and Ganglioneuromatosis in a Dog

Résumé

A 5-month-old female Great Dane puppy was treated for hematochezia, tenesmus, and rectal prolapse by resection of a 10-cm-long segment of colon and rectum. Grossly, the colorectal segment had diffuse mucosal and submucosal thickening with multiple polypoid nodules. The histologic diagnosis was colorectal hamartomatous polyps with ganglioneuromatosis. Duplication of PTEN was detected by quantitative multiplex polymerase chain reaction testing. The presence of 2 hamartomatous colorectal lesions with PTEN mutation is similar to human Cowden syndrome.
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hal-02646823 , version 1 (29-05-2020)

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I. Bemelmans, S. Küry, Olivier Albaric, Juliette Hordeaux, L. Bertrand, et al.. Colorectal Hamartomatous Polyposis and Ganglioneuromatosis in a Dog. Veterinary Pathology, 2011, 48 (5), pp.1012-1015. ⟨10.1177/0300985810384411⟩. ⟨hal-02646823⟩
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