%0 Journal Article %T (E)-N'-(1-(3-oxo-3H-benzo[f]chromen-2-yl)ethylidene)benzohydrazide protecting rat heart tissues from isoproterenol toxicity: Evidence from in vitro and in vivo tests %+ Université de Sfax - University of Sfax %+ Faculté des Sciences de Gafsa %+ Université de Sousse %+ Institut des Sciences Chimiques de Rennes (ISCR) %A Emna, Khdhiri %A Mnafgui, Kais %A Ghazouani, Lakhdar %A Feriani, Anouar %A Hajji, Raouf %A Bouzanna, Walid %A Allouche, Noureddine %A Bazureau, Jean-Pierre %A Ammar, Houcine %A Abid, Souhir %Z Ministry of Higher Education and Scientific Research %Z Ministry of Public Health %< avec comité de lecture %@ 0014-2999 %J European Journal of Pharmacology %I Elsevier %V 881 %P 173137 %8 2020 %D 2020 %R 10.1016/j.ejphar.2020.173137 %M 32380016 %K ACE %K E)-N’-(1-(3-oxo-3H-benzo[f]chromen-2-yl)ethylidene)benzohydrazide %K Isoproterenol %K Myocardial infarction %K Thrombolytic %Z Life Sciences [q-bio] %Z Chemical SciencesJournal articles %X The current study was aimed to assess the protective effect of a new molecule (E)-N'-(1-(3-oxo-3H-benzo[f]chromen-2-yl)ethylidene)benzohydrazide, denoted 1c, against cardiac remodeling process in isoproterenol (Isop) induced myocardial infarction (MI) in rats. Male Wistar rats were randomly divided into four groups, control, Isop (85 mg/kg body weight was injected subcutaneously into rats at an interval of 24 h for 2 days (6 and 7 day) to induce MI and pretreated animals with acenocoumarol (Ace) (150 μg/kg bw) and 1c (150 μg/kg bw) by oral administration during 7 days and injected with isoproterenol (Isop + Ace) and (Isop + 1c) groups. Results in vitro showed that 1c is endowed with potent inhibition of angiotensin-converting enzyme (ACE) with an IC 39.12 μg/ml. The in vivo exploration evidenced alteration in the ECG pattern, notable cardiac hypertrophy and increase in plasma level of fibrinogen, troponin-T, CK-MB and LDH, AST and ALT by 171%, 300%, 50%, 64% and 75% respectively with histological myocardium necrosis and cells inflammatory infiltration. However, pre-treatment with 1c improved the ECG pattern reduced significantly the cardiac dysfunction markers and ameliorated the thrombolytic process by decreasing fibrinogen level as compared to untreated infracted rats. Overall, (E)-N'-(1-(3-oxo-3H-benzo[f]chromen-2-yl)ethylidene)benzohydrazide 1c could be used as anticoagulant agent to prevent thrombosis in acute myocardial infarction. %G English %2 https://univ-rennes.hal.science/hal-02635141/document %2 https://univ-rennes.hal.science/hal-02635141/file/Emna%20et%20al-2020-%28E%29-N%E2%80%99-%281-%283-oxo-3H-benzo%5Bf%5Dchromen-2-yl%29ethylidene%29benzohydrazide%20protecting.pdf %L hal-02635141 %U https://univ-rennes.hal.science/hal-02635141 %~ UNIV-RENNES1 %~ CNRS %~ INSA-RENNES %~ ENSC-RENNES %~ ISCR %~ SCR_ICMV %~ STATS-UR1 %~ UR1-SPM %~ INC-CNRS %~ UR1-UFR-SPM %~ UR1-HAL %~ ISCR-CORINT %~ UR1-SDLM %~ TEST-UR-CSS %~ UNIV-RENNES %~ INSA-GROUPE %~ ISCR-CORINT1 %~ TEST-HALCNRS %~ UR1-MMS %~ TEST2-HALCNRS %~ TEST3-HALCNRS