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Article Dans Une Revue Journal of Antimicrobial Chemotherapy Année : 2018

Population pharmacokinetics of daptomycin in critically ill patients with various degrees of renal impairment

Martine Ferrandiere
Sigismond Lasocki
Thomas Gaillard

Résumé

The objective of this study was to characterize the pharmacokinetics of unbound and total concentrations of daptomycin in infected ICU patients with various degrees of renal impairment. From these results, the probability of attaining antimicrobial efficacy and the risks of toxicity were assessed.

Dates et versions

hal-02477959 , version 1 (13-02-2020)

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Citer

Nicolas Grégoire, Sandrine Marchand, Martine Ferrandiere, Sigismond Lasocki, Philippe Seguin, et al.. Population pharmacokinetics of daptomycin in critically ill patients with various degrees of renal impairment. Journal of Antimicrobial Chemotherapy, 2018, 74 (1), pp.117-125. ⟨10.1093/jac/dky374⟩. ⟨hal-02477959⟩
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