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Journal Articles Nature Human Behaviour Year : 2019

Identification of neurobehavioural symptom groups based on shared brain mechanisms

Alex Ing
  • Function : Author
Thomas Wolfers
  • Function : Author
Tobias Banaschewski
Arun L. W. Bokde
  • Function : Author
Uli Bromberg
  • Function : Author
Christian Büchel
  • Function : Author
Patricia Conrod
  • Function : Author
Tahmine Fadai
  • Function : Author
Herta Flor
  • Function : Author
Vincent Frouin
  • Function : Author
Hugh Garavan
  • Function : Author
Philip A. Spechler
  • Function : Author
Penny Gowland
  • Function : Author
Yvonne Grimmer
  • Function : Author
Andreas Heinz
  • Function : Author
Bernd Ittermann
  • Function : Author
Viola Kappel
  • Function : Author
Andreas Meyer-Lindenberg
  • Function : Author
Sabina Millenet
  • Function : Author
Frauke Nees
  • Function : Author
Betteke Van Noort
  • Function : Author
Jani Penttilä
  • Function : Author
Luise Poustka
  • Function : Author
Erin Burke Quinlan
  • Function : Author
Michael N. Smolka
  • Function : Author
Argyris Stringaris
  • Function : Author
Maren Struve
  • Function : Author
Ilya M. Veer
  • Function : Author
Henrik Walter
  • Function : Author
Robert Whelan
  • Function : Author
Ole A. Andreassen
  • Function : Author
Ingrid Agartz
  • Function : Author
Edward D. Barker
  • Function : Author
John Ashburner
  • Function : Author
Elisabeth Binder
Jan Buitelaar
  • Function : Author
Andre Marquand
  • Function : Author
Trevor W. Robbins
  • Function : Author

Abstract

Most psychopathological disorders develop in adolescence. The biological basis for this development is poorly understood. To enhance diagnostic characterization and develop improved targeted interventions, it is critical to identify behavioural symptom groups that share neural substrates. We ran analyses to find relationships between behavioural symptoms and neuroimaging measures of brain structure and function in adolescence. We found two symptom groups, consisting of anxiety/depression and executive dysfunction symptoms, respectively, that correlated with distinct sets of brain regions and inter-regional connections, measured by structural and functional neuroimaging modalities. We found that the neural correlates of these symptom groups were present before behavioural symptoms had developed. These neural correlates showed case-control differences in corresponding psychiatric disorders, depression and attention deficit hyperactivity disorder in independent clinical samples. By characterizing behavioural symptom groups based on shared neural mechanisms, our results provide a framework for developing a classification system for psychiatric illness that is based on quantitative neurobehavioural measures.
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Dates and versions

hal-02443809 , version 1 (12-02-2020)

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Alex Ing, Philipp G. Sämann, Congying Chu, Nicole Tay, Francesca Biondo, et al.. Identification of neurobehavioural symptom groups based on shared brain mechanisms. Nature Human Behaviour, 2019, 3 (12), pp.1306-1318. ⟨10.1038/s41562-019-0738-8⟩. ⟨hal-02443809⟩
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