%0 Journal Article %T Post-transcriptional regulation in cancer %+ Institut de Génétique et Développement de Rennes (IGDR) %+ The University of New Mexico [Albuquerque] %A Audic, Yann %A Hartley, Rebecca, S %< avec comité de lecture %@ 0248-4900 %J Biology of the Cell %I Wiley %V 96 %N 7 %P 479-498 %8 2004-09 %D 2004 %R 10.1016/j.biolcel.2004.05.002 %M 15380615 %Z Life Sciences [q-bio]Journal articles %X Deregulation of gene expression is a hallmark of the cancer cell. Acquiring a new profile of expressed proteins may enable the cell to re-enter the cell cycle, or give them a growth or motility advantage over "normal cells". An efficient and rapid way to alter gene expression is via regulation of mRNAs already transcribed. Modifications of mRNA stability and/or translational efficiency are increasingly reported in cancer. mRNA stability and translation are controlled through a complex network of RNA/protein interactions involving recognition of specific target mRNAs by RNA-BPs. We review how alterations in regulatory sequences, RNA-BPs, or in upstream signalling pathways affect the stability and/or translational efficiency of mRNAs encoding proto-oncogenes, cytokines, cell cycle regulators and other regulatory proteins to promote tumorigenesis and cancer progression. A more thorough understanding of post-transcriptional mechanisms such as these will enable the design and development of specific therapies based on modulating the translation or stability of specific mRNAs. %G English %L hal-02323363 %U https://univ-rennes.hal.science/hal-02323363 %~ UNIV-RENNES1 %~ CNRS %~ IFR140 %~ IGDR %~ IGDR-EGD %~ UR1-UFR-SVE %~ UR1-HAL %~ UR1-SDV %~ TEST-UR-CSS %~ UNIV-RENNES %~ UR1-BIO-SA