Biocompatible conjugated fluorenylporphyrins for two-photon photodynamic therapy and fluorescence imaging
Résumé
The photophysical properties of a new series of fluorenyl porphyrins bearing water-solubilising oligoethyleneglycol chains are described. These biocompatible compounds present very good two-photon absorption and singlet oxygen generation properties, while retaining some fluorescence in water. After testing in vitro on breast cancer cells, some of them were shown to be efficient non-toxic two-photon photosensitisers allowing for fluorescence imaging, thus demonstrating their theranostic potential.
Domaines
Chimie thérapeutique
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Shi et al-2019-Biocompatible conjugated fluorenylporphyrins.pdf (636.93 Ko)
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