%0 Journal Article %T Transforming Growth Factor-Beta (TGFβ) Signaling Pathway in Cholangiocarcinoma %+ Nutrition, Métabolismes et Cancer (NuMeCan) %A Papoutsoglou, Panagiotis %A Louis, Corentin %A Coulouarn, Cédric %Z C18007NS, Institut National de la Santé et de la Recherche Médicale %Z C18007NS, INCa, and ITMO Cancer AVIESAN (Alliance Nationale pour les Sciences de la Vie et de la Santé) dans le cadre du Plan cancer (Non-coding RNA in cancerology fundamental to translational %Z dotation, Université de Rennes 1 %< avec comité de lecture %@ 2073-4409 %J Cells %I MDPI %V 8 %N 9 %P E960 %8 2019-08-23 %D 2019 %R 10.3390/cells8090960 %M 31450767 %K noncoding RNA %K liver cancer %K signaling %K TGFβ %K cholangiocarcinoma %Z Life Sciences [q-bio]Journal articles %X Cholangiocarcinoma is a deadly cancer worldwide, associated with a poor prognosis and limited therapeutic options. Although cholangiocarcinoma accounts for less than 15% of liver primary cancer, its silent nature restricts early diagnosis and prevents efficient treatment. Therefore, it is of clinical relevance to better understand the molecular basis of cholangiocarcinoma, including the signaling pathways that contribute to tumor onset and progression. In this review, we discuss the genetic, molecular, and environmental factors that promote cholangiocarcinoma, emphasizing the role of the transforming growth factor beta (TGF beta) signaling pathway in the progression of this cancer. We provide an overview of the physiological functions of TGF beta signaling in preserving liver homeostasis and describe how advanced cholangiocarcinoma benefits from the tumor-promoting effects of TGF beta. Moreover, we report the importance of noncoding RNAs as effector molecules downstream of TGF beta during cholangiocarcinoma progression, and conclude by highlighting the need for identifying novel and clinically relevant biomarkers for a better management of patients with cholangiocarcinoma. %G English %2 https://univ-rennes.hal.science/hal-02281403/document %2 https://univ-rennes.hal.science/hal-02281403/file/2019_Papoutsoglou_cells_1.pdf %L hal-02281403 %U https://univ-rennes.hal.science/hal-02281403 %~ INSERM %~ UNIV-RENNES1 %~ STATS-UR1 %~ NUMECAN %~ NUMECAN-TGTC %~ UR1-UFR-SVE %~ UR1-HAL %~ UR1-SDV %~ TEST-UR-CSS %~ UNIV-RENNES %~ UR1-BIO-SA