%0 Journal Article %T Lichen butyrolactone derivatives disrupt oral bacterial membrane %+ Nutrition, Métabolismes et Cancer (NuMeCan) %+ Institut des Sciences Chimiques de Rennes (ISCR) %+ Centre de Microscopie de Rennes (MRic) %+ Chemistry, Oncogenesis, Stress and Signaling (COSS) %+ Lebanese University [Beirut] (LU) %A Sweidan, Alaa %A Smida, Imen %A Chollet-Krugler, Marylene %A Sauvager, Aurélie %A Vallet, Julien %A Gouault, Nicolas %A Oliviero, Nolwenn %A Tamanai-Shacoori, Zohreh %A Burel, Agnès %A van de Weghe, Pierre %A Chokr, Ali %A Tomasi, Sophie %A Bousarghin, Latifa %Z Rennes I University %Z Association of Specialization and Scientific Orientation %< avec comité de lecture %@ 0367-326X %J Fitoterapia %I Elsevier %V 137 %P 104274 %8 2019-09 %D 2019 %R 10.1016/j.fitote.2019.104274 %M 31344394 %K Butyrolactone %K Cell wall %K Porphyromanas gingivalis %K Streptococcus gordonii %K Lichen %Z Chemical Sciences/Medicinal Chemistry %Z Life Sciences [q-bio]/Pharmaceutical sciences/PharmacologyJournal articles %X We have previously demonstrated that out of the butyrolactones series synthesized based on the natural lichen metabolite lichesterinic acid, compound (B-13) was the most effective against oral bacteria. However, its antibacterial mechanism is still unknown. In this study, we have investigated its bacterial localization by synthesizing a fluorescently labeled B-13 with NBD while maintaining its antibacterial activity. We showed that this compound binds to Streptococcus gordonii cell surface, as demonstrated by HPLC analysis. By adhering to cell surface, B-13 induced cell wall disruption leading to the release of bacterial constituents and consequently, the death of S. gordonii, a Gram-positive bacterium. A Gram-negative counterpart, Porphyromanas gingivalis, showed also cracked and ruptured cells in the presence of B-13. Besides, we also demonstrated that the analog of B-13, B-12, has also induced disruption of P. gingivalis and S. gordonii. This study revealed that butyrolactones can be considered as potent antibacterial compounds against oral pathogens causing medical complications. %G English %2 https://univ-rennes.hal.science/hal-02280840/document %2 https://univ-rennes.hal.science/hal-02280840/file/Sweidan-2019-Lichen%20butyrolactone%20derivatives.pdf %L hal-02280840 %U https://univ-rennes.hal.science/hal-02280840 %~ UNIV-RENNES1 %~ CNRS %~ INSA-RENNES %~ ENSC-RENNES %~ INRA %~ IFR140 %~ FNCLCC %~ MARQUIS %~ ISCR %~ SCR-PNSCM %~ STATS-UR1 %~ BIOSIT %~ OSS %~ NUMECAN %~ UR1-SPM %~ INC-CNRS %~ NUMECAN-CIMIAD %~ UR1-UFR-SVE %~ UR1-UFR-SPM %~ UR1-HAL %~ ISCR-CORINT %~ UR1-SDLM %~ UR1-SDV %~ AGREENIUM %~ TEST-UR-CSS %~ UNIV-RENNES %~ INSA-GROUPE %~ ISCR-CORINT1 %~ TEST-HALCNRS %~ NUMECAN-METHER %~ UR1-MMS %~ UR1-BIO-SA %~ ISCR-CORINT3 %~ TEST2-HALCNRS