%0 Journal Article %T The ex vivo human lung research value for translational science %+ University of California [San Francisco] (UC San Francisco) %+ CHU Pontchaillou [Rennes] %+ Centre d'Investigation Clinique [Rennes] (CIC) %+ Nutrition, Métabolismes et Cancer (NuMeCan) %+ Vanderbilt University School of Medicine [Nashville] %A Ross, James T %A Nesseler, Nicolas %A Lee, Jae-Woo %A Ware, Lorraine B %A Matthay, Michael A %Z NIH [T32DK007573-23, HL135849, HL126176, HL126456, HL140026, HL134828]; Société Française d'Anesthésie-Réanimation (Paris, France); Journées Rennaises d'Anesthésie-Réanimation association (Rennes, France); National Heart, Lung, and Blood Institute [HL113022]; UCSF Nina Ireland Program for Lung Health; Association Chirurgicale pour le Développement et l'Amélioration des Techniques de Dépistage de Traitement des Maladies Cardiovasculaires (Paris, France) %< avec comité de lecture %@ 2379-3708 %J JCI Insight %I American Society for Clinical Investigation %V 4 %N 11 %P 128833 %8 2019-06-06 %D 2019 %R 10.1172/jci.insight.128833 %M 31167972 %K protein permeability %K pulmonary-edema %K mesenchymal stem-cells %K alveolar fluclearance %K stromal cells %Z Life Sciences [q-bio]Journal articles %X Respiratory diseases are among the leading causes of death and disability worldwide. However, the pathogenesis of both acute and chronic lung diseases remains incompletely understood. As a result, therapeutic options for important clinical problems, including acute respiratory distress syndrome and chronic obstructive pulmonary disease, are limited. Research efforts have been held back in part by the difficulty of modeling lung injury in animals. Donor human lungs that have been rejected for transplantation offer a valuable alternative for understanding these diseases. In 2007, our group developed a simple preparation of an ex vivo-perfused single human lung. In this Review, we discuss the availability of donor human lungs for research, describe the ex vivo-perfused lung preparation, and highlight how this preparation can be used to study the mechanisms of lung injury, to isolate primary cells, and to test novel therapeutics. %G English %L hal-02179155 %U https://univ-rennes.hal.science/hal-02179155 %~ UNIV-RENNES1 %~ INRA %~ HL %~ CIC %~ CIC203 %~ STATS-UR1 %~ NUMECAN %~ NUMECAN-EXPRES %~ UR1-UFR-SVE %~ UR1-HAL %~ UR1-SDV %~ AGREENIUM %~ TEST-UR-CSS %~ UNIV-RENNES %~ UR1-BIO-SA