Impact of maternal body mass index and gestational weight gain on pregnancy complications: An individual participant data meta-analysis of European, North American and Australian cohorts - Université de Rennes Access content directly
Journal Articles BJOG: An International Journal of Obstetrics and Gynaecology Year : 2019

Impact of maternal body mass index and gestational weight gain on pregnancy complications: An individual participant data meta-analysis of European, North American and Australian cohorts

Susana Santos (1) , Ellis Voerman (1) , Pilar Amiano , Henrique Barros , Lawrence J Beilin , Anna Bergström , Marie-Aline Charles (2) , Leda Chatzi (3) , Cécile Chevrier (4) , George P Chrousos , Eva Corpeleijn , Olga Costa , Nathalie Costet (4) , Sarah Crozier , Graham Devereux , Myriam Doyon , Merete Eggesbø , Maria Pia Fantini , Sara Farchi , Francesco Forastiere (5) , Vagelis Georgiu , Keith M Godfrey , Davide Gori , Veit Grote , Wojciech Hanke , Irva Hertz-Picciotto , Barbara Heude (2) , Marie-France Hivert , Daniel Hryhorczuk , Rae-Chi Huang , Hazel Inskip , Anne M Karvonen , Louise C Kenny , Berthold Koletzko , Leanne K Küpers , Irina Lehmann , Renata Majewska , Johanna Mäkelä , Yannis Manios , Fionnuala M Mcauliffe , Sheila W Mcdonald , John Mehegan , Erik Melen , Monique Mommers , Camilla S Morgen , George Moschonis , Deirdre Murray , Carol Ní Chaoimh , Ellen A Nohr , Anne-Marie Nybo Andersen , Emily Oken , Adriëtte J J M Oostvogels , Agnieszka Pac , Eleni Papadopoulou , Juha Pekkanen , Costanza Pizzi , Kinga Polanska , Daniela Porta , Lorenzo Richiardi , Sheryl L Rifas-Shiman , Nel Roeleveld , Luca Ronfani , Ana C Santos , Marie Standl , Hein Stigum (6) , Camilla Stoltenberg , Elisabeth Thiering , Carel Thijs , Maties Torrent , Suzanne C Tough , Tomas Trnovec , Steve Turner , Marleen M H J van Gelder , Lenie van Rossem , Andrea von Berg , Martine Vrijheid , Tanja Vrijkotte , Jane West , Alet H Wijga , John Wright , Oleksandr Zvinchuk , I A Thorkild , Debbie A. Lawlor , Romy Gaillard , Vincent W V Jaddoe
Pilar Amiano
  • Function : Author
  • PersonId : 914519
Henrique Barros
  • Function : Author
Lawrence J Beilin
  • Function : Author
Anna Bergström
  • Function : Author
  • PersonId : 936559
George P Chrousos
  • Function : Author
Eva Corpeleijn
  • Function : Author
Olga Costa
  • Function : Author
Sarah Crozier
  • Function : Author
  • PersonId : 903315
Graham Devereux
  • Function : Author
Myriam Doyon
  • Function : Author
Merete Eggesbø
  • Function : Author
Maria Pia Fantini
  • Function : Author
Sara Farchi
  • Function : Author
Francesco Forastiere
Vagelis Georgiu
  • Function : Author
Keith M Godfrey
  • Function : Author
Davide Gori
  • Function : Author
Veit Grote
Wojciech Hanke
  • Function : Author
Irva Hertz-Picciotto
  • Function : Author
Marie-France Hivert
Daniel Hryhorczuk
  • Function : Author
Rae-Chi Huang
Hazel Inskip
  • Function : Author
  • PersonId : 903313
Anne M Karvonen
  • Function : Author
Louise C Kenny
  • Function : Author
Berthold Koletzko
  • Function : Author
Leanne K Küpers
  • Function : Author
Irina Lehmann
  • Function : Author
Renata Majewska
  • Function : Author
Johanna Mäkelä
  • Function : Author
Yannis Manios
  • Function : Author
Fionnuala M Mcauliffe
  • Function : Author
Sheila W Mcdonald
  • Function : Author
John Mehegan
  • Function : Author
  • PersonId : 931361
Erik Melen
  • Function : Author
Monique Mommers
  • Function : Author
Camilla S Morgen
  • Function : Author
George Moschonis
  • Function : Author
Deirdre Murray
  • Function : Author
Carol Ní Chaoimh
  • Function : Author
Ellen A Nohr
  • Function : Author
Anne-Marie Nybo Andersen
  • Function : Author
Emily Oken
  • Function : Author
Adriëtte J J M Oostvogels
  • Function : Author
Agnieszka Pac
  • Function : Author
Eleni Papadopoulou
  • Function : Author
Juha Pekkanen
  • Function : Author
Costanza Pizzi
  • Function : Author
  • PersonId : 897060
Kinga Polanska
  • Function : Author
Daniela Porta
  • Function : Author
Lorenzo Richiardi
  • Function : Author
Sheryl L Rifas-Shiman
  • Function : Author
Nel Roeleveld
  • Function : Author
Luca Ronfani
  • Function : Author
Ana C Santos
  • Function : Author
Marie Standl
Camilla Stoltenberg
  • Function : Author
Elisabeth Thiering
  • Function : Author
Carel Thijs
  • Function : Author
Maties Torrent
  • Function : Author
Suzanne C Tough
  • Function : Author
Tomas Trnovec
  • Function : Author
Steve Turner
Marleen M H J van Gelder
  • Function : Author
Lenie van Rossem
  • Function : Author
Andrea von Berg
  • Function : Author
Martine Vrijheid
Tanja Vrijkotte
  • Function : Author
  • PersonId : 905800
Jane West
  • Function : Author
Alet H Wijga
  • Function : Author
John Wright
  • Function : Author
Oleksandr Zvinchuk
  • Function : Author
I A Thorkild
  • Function : Author
Debbie A. Lawlor
  • Function : Author
Romy Gaillard
Vincent W V Jaddoe
  • Function : Correspondent author

Abstract

Objective - To assess the separate and combined associations of maternal pre-pregnancy body mass index (BMI) and gestational weight gain with the risks of pregnancy complications and their population impact. Design - Individual participant data meta-analysis of 39 cohorts. Setting - Europe, North America, and Oceania. Population - 265 270 births. Methods - Information on maternal pre-pregnancy BMI, gestational weight gain, and pregnancy complications was obtained. Multilevel binary logistic regression models were used. Main outcome measures - Gestational hypertension, pre-eclampsia, gestational diabetes, preterm birth, small and large for gestational age at birth. Results - Higher maternal pre-pregnancy BMI and gestational weight gain were, across their full ranges, associated with higher risks of gestational hypertensive disorders, gestational diabetes, and large for gestational age at birth. Preterm birth risk was higher at lower and higher BMI and weight gain. Compared with normal weight mothers with medium gestational weight gain, obese mothers with high gestational weight gain had the highest risk of any pregnancy complication (odds ratio 2.51, 95% CI 2.31- 2.74). We estimated that 23.9% of any pregnancy complication was attributable to maternal overweight/obesity and 31.6% of large for gestational age infants was attributable to excessive gestational weight gain. Conclusions - Maternal pre-pregnancy BMI and gestational weight gain are, across their full ranges, associated with risks of pregnancy complications. Obese mothers with high gestational weight gain are at the highest risk of pregnancy complications. Promoting a healthy pre-pregnancy BMI and gestational weight gain may reduce the burden of pregnancy complications and ultimately the risk of maternal and neonatal morbidity. Tweetable abstract - Promoting a healthy body mass index and gestational weight gain might reduce the population burden of pregnancy complications.
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Dates and versions

hal-02177554 , version 1 (09-07-2019)

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Susana Santos, Ellis Voerman, Pilar Amiano, Henrique Barros, Lawrence J Beilin, et al.. Impact of maternal body mass index and gestational weight gain on pregnancy complications: An individual participant data meta-analysis of European, North American and Australian cohorts. BJOG: An International Journal of Obstetrics and Gynaecology, 2019, 126 (8), pp.984-995. ⟨10.1111/1471-0528.15661⟩. ⟨hal-02177554⟩
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