Further terpenoids from Euphorbia tirucalli - Université de Rennes Access content directly
Journal Articles Fitoterapia Year : 2019

Further terpenoids from Euphorbia tirucalli


The phytochemical investigation of Euphorbia tirucalli L. (Euphorbiaceae) yielded four new compounds, including a rare cadalene-type sesquiterpene (tirucadalenone), two tirucallane triterpenoids, euphorol L and euphorol M, with the latter being described as an epimeric mixture, and a euphane triterpene, namely, euphorol N, together with 7 known compounds. Their structures and absolute configurations were elucidated from analysis of 1D (1H, J-modulated C) and 2D NMR (HSQC, HMBC and NOESY), high-resolution mass spectrometry (HRESIMS), optical rotation, and GIAO NMR shift calculation followed by CP3 analysis, along with comparison with literature reports. All these compounds were tested for cytotoxicity against K562, MCF-7 and/or and HepG2 tumor cell lines. Only tirucadalenone displayed a mild cytotoxic activity.
Fichier principal
Vignette du fichier
Duong et al-2019-Further terpenoids from Euphorbia tirucalli.pdf (1.16 Mo) Télécharger le fichier
Origin : Files produced by the author(s)

Dates and versions

hal-02120745 , version 1 (21-06-2019)



Thuc-Huy Duong, Mehdi A Beniddir, Grégory Genta-Jouve, Huu-Hung Nguyen, Dinh-Phuoc Nguyen, et al.. Further terpenoids from Euphorbia tirucalli. Fitoterapia, 2019, 135, pp.44-51. ⟨10.1016/j.fitote.2019.04.001⟩. ⟨hal-02120745⟩
158 View
278 Download



Gmail Facebook X LinkedIn More