%0 Journal Article %T Transarterial Radioembolization (TARE) Agents beyond Y-90-Microspheres %+ Institut des Sciences Chimiques de Rennes (ISCR) %+ CRLCC Eugène Marquis (CRLCC) %+ Laboratoire Traitement du Signal et de l'Image (LTSI) %+ Nutrition, Métabolismes et Cancer (NuMeCan) %A Bouvry, C. %A Palard, X. %A Edeline, J. %A Ardisson, V. %A Loyer, P. %A Garin, E. %A Lepareur, Nicolas %Z Labex IRON [ANR-11-LABX-0018] %< avec comité de lecture %@ 2314-6133 %J BioMed Research International %I Hindawi Publishing Corporation %V 2018 %P 1435302 %8 2018-12-31 %D 2018 %R 10.1155/2018/1435302 %M 30687734 %K poly(l-lactic acid) microspheres %K inoperable hepatocellular-carcinoma %K internal radiation-therapy %K ho-166 loaded microspheres %K serum-albumin microspheres %K hepatic-artery injection %K liver-cancer %K radionuclide therapy %K intraarterial injection %K i-131-labeled lipiodol %Z Life Sciences [q-bio]/Bioengineering/Nuclear medicineJournal articles %X Liver malignancies, either primary tumours (mainly hepatocellular carcinoma and cholangiocarcinoma) or secondary hepatic metastases, are a major cause of death, with an increasing incidence. Among them, hepatocellular carcinoma (HCC) presents with a dark prognosis because of underlying liver diseases and an often late diagnosis. A curative surgical treatment can therefore only be proposed in 20 to 30% of the patients. However, new treatment options for intermediate to advanced stages, such as internal radionuclide therapy, seem particularly attractive. Transarterial radioembolization (TARE), which consists in the use of intra-arterial injection of a radiolabelled embolising agent, has led to very promising results. TARE with Y-90-loaded microspheres is now becoming an established procedure to treat liver tumours, with two commercially available products (namely, SIR-Sphere (R) and TheraSphere (R)). However, this technology remains expensive and is thus not available everywhere. The aim of this review is to describe TARE alternative technologies currently developed and investigated in clinical trials, with special emphasis on HCC. %G English %2 https://univ-rennes.hal.science/hal-02049234/document %2 https://univ-rennes.hal.science/hal-02049234/file/1435302.pdf %L hal-02049234 %U https://univ-rennes.hal.science/hal-02049234 %~ INSERM %~ UNIV-RENNES1 %~ CNRS %~ INSA-RENNES %~ ENSC-RENNES %~ INRA %~ LTSI %~ FNCLCC %~ MARQUIS %~ ISCR %~ STATS-UR1 %~ NUMECAN %~ UR1-SPM %~ INC-CNRS %~ NUMECAN-TGTC %~ UR1-UFR-SVE %~ UR1-UFR-SPM %~ UR1-HAL %~ UR1-MATH-STIC %~ UR1-SDLM %~ UR1-SDV %~ AGREENIUM %~ TEST-UR-CSS %~ UNIV-RENNES %~ INSA-GROUPE %~ TEST-HALCNRS %~ NUMECAN-METHER %~ ANR %~ UR1-MATH-NUM %~ UR1-MMS %~ UR1-BIO-SA %~ TEST2-HALCNRS