%0 Journal Article %T Propionic fermentation by the probiotic Propionibacterium freudenreichii to functionalize whey %+ Soochow University %+ Science et Technologie du Lait et de l'Oeuf (STLO) %+ Nutrition, Métabolismes et Cancer (NuMeCan) %A Huang, S. %A Rabah, H. %A Ferret-Bernard, Stéphanie %A Le Normand, L. %A Guerin, S. %A Nogret, I. %A Gaucher, Floriane %A Le Loir, Yves %A Chen, X.D. %A Jan, Gwénaël %A Boudry, Gaëlle %A Jeantet, Romain %Z 2015/0747, The French association Brittany Food Biotechnology (Bba), the Brittany Region and The National Association of Research and Technology %< avec comité de lecture %@ 1756-4646 %J Journal of Functional Foods %I Elsevier %V 52 %P 620-628 %8 2019-01 %D 2019 %R 10.1016/j.jff.2018.11.043 %K Functional food %K Immunomodulation %K Whey %K T lymphocytes phenotype %K P. freudenreichii %Z Life Sciences [q-bio]Journal articles %X A new probiotic functionalized sweet whey was evaluated. Weaned healthy piglets consumed sweet whey (SW), unmodified or fermented by P. freudenreichii CIRM-BIA 129 (PF-SW). Fecal short chain fatty acids amounts remained unchanged. Bifidobacteria were enhanced in the PF-SW group, and so was the expression of T-bet, which orchestrates Th1 differentiation of T lymphocytes, in mesenteric lymph nodes immune cells (MLNC). This was consistent with ex vivo increased TNF-α secretion by MLNC in response to lipopolysaccharide (LPS). The consumption of the functionalized whey induced a different response in peripheral blood mononuclear cells (PBMC) to ex vivo stimulations, as the inhibition of TNF-α secretion in response to concanavalin A stimulation. Thus, by cultivating a probiotic GRAS bacterium in concentrated whey, prior to spray drying, it is possible to transform this by-product into a functional ingredient. This opens new avenues for the development of functional ingredients through enhanced valorisation of whey. %G English %L hal-02043531 %U https://univ-rennes.hal.science/hal-02043531 %~ UNIV-RENNES1 %~ INRA %~ UNAM %~ STATS-UR1 %~ NUMECAN %~ NUMECAN-ALICE %~ UR1-UFR-SVE %~ UR1-HAL %~ UR1-SDV %~ AGREENIUM %~ TEST-UR-CSS %~ UNIV-RENNES %~ INRAE %~ STLO %~ NUMECAN-EAT %~ UR1-BIO-SA %~ INSTITUT-AGRO-RENNES-ANGERS-UMR-STLO %~ INSTITUT-AGRO-RENNES-ANGERS %~ INSTITUT-AGRO-STLO %~ ALIMH %~ INSTITUT-AGRO %~ PUBLIS-EC-IA