%0 Journal Article %T Selective serotonin reuptake inhibitor effects on neural biomarkers of perinatal depression %+ Institut de recherche en santé, environnement et travail (Irset) %+ École des Hautes Études en Santé Publique [EHESP] (EHESP) %+ University of British Columbia (UBC) %A Pawluski, Jodi L %A Brain, Ursula %A Hammond, Geoffrey L %A Oberlander, Tim F %< avec comité de lecture %@ 1434-1816 %J Archives of Women's Mental Health %I Springer Verlag %V 22 %N 3 %P 431-435 %8 2019-06 %D 2019 %R 10.1007/s00737-018-0931-1 %M 30506371 %K Motherhood %K Anxiety %K Neuroplasticity %K Antidepressants %K Depression %K Gestation %Z Life Sciences [q-bio] %Z Life Sciences [q-bio]/Human health and pathology/Psychiatrics and mental health %Z Life Sciences [q-bio]/Santé publique et épidémiologieJournal articles %X The effect of perinatal selective serotonin reuptake inhibitors (SSRIs) on brain-derived neurotrophic factor (BDNF) and S100 calcium binding protein B (S100B) has not been investigated. Using a cohort of 86 pregnant women, we found that SSRIs significantly increase BDNF levels in late pregnancy and that S100B, but not BDNF, is associated with maternal depression in SSRI-treated women only. This shows that serum S100B could be a unique biomarker to determine efficacy of SSRIs during gestation. %G English %2 https://univ-rennes.hal.science/hal-01976469/document %2 https://univ-rennes.hal.science/hal-01976469/file/Pawluski_Selective%20Serotonin%20Reuptake%20Inhibitor%20Effects_Accepted.pdf %L hal-01976469 %U https://univ-rennes.hal.science/hal-01976469 %~ UNIV-RENNES1 %~ UNIV-ANGERS %~ SANTE_PUB_INSERM %~ IFR140 %~ IRSET %~ STATS-UR1 %~ IRSET-SMS %~ IRSET-CCII %~ IRSET-TREC %~ IRSET-HIAEC %~ IRSET-SMLF %~ IRSET-ERD %~ IRSET-VCER %~ IRSET-NEED %~ IRSET-TNGC %~ UR1-UFR-SVE %~ UR1-HAL %~ UR1-SDV %~ TEST-UR-CSS %~ UNIV-RENNES %~ UR1-BIO-SA