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              <p>CFTR protein regulates electrolyte and fluid transport in almost all tissues with exocrine function, including male reproductive tract. Mutation of CFTR gene causes cystic fibrosis (CF), which affects the function of several organs, and impairs male fertility. The role of CFTR protein in different compartments of male reproductive tract (testis, epididymis, sperm) as well as an impact of CFTR mutation(s) on male fertility phenotype is discussed in relation with the choice of optimal technique for Assisted Reproductive Techniques (ART) management.</p>
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              <p>La protéine CFTR est un canal chlore régulant le transport de fluides et d'électrolytes danspresque tous les tissus ayant une fonction exocrine, y compris les voies génitales masculines. Des mutations du gène codant pour cette protéine sont responsables de la mucoviscidose, maladie génétique la plus fréquente en Europe, et de l'aplasie congénitale des canaux déférents. Le rôle joué par la protéine CFTR dans les différents compartiments de l’appareil génital mâle (testicule, épididyme, gamète) ainsi que l’impact d’une mutation CFTR sur le phénotype de fertilité masculine et sa prise en charge thérapeutique sont discutés dans cette revue.</p>
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