HIBISCUS: Hydroxychloroquine for the secondary prevention of thrombotic and obstetrical events in primary antiphospholipid syndrome
Cristina Belizna
(1, 2)
,
Francesca Pregnolato
(3)
,
Sébastien Abad
(4, 5)
,
Jaume Alijotas-Reig
(6)
,
Howard Amital
(7)
,
Zahir Amoura
(8)
,
Laura Andreoli
(9)
,
Emmanuel Andres
(10)
,
Achile Aouba
(11)
,
Sule Apras Bilgen
(12)
,
Laurent Arnaud
(10)
,
Boris Bienvenu
(13)
,
Viktoria Bitsadze
(14)
,
Patrick Blanco
(15)
,
Miri Blank
(7)
,
Maria Borghi
(16)
,
Antonia Caligaro
(17)
,
Elisabeta Candrea
(18)
,
Valentina Canti
(16)
,
Laurent Chiche
(19)
,
Jean Chrétien
(1)
,
Jan Willem Cohen Tervaert
(20, 21)
,
Laura Damian
(22)
,
Teresa Delross
(17)
,
Emmanuelle Dernis
(23)
,
Katrien Devreese
(24)
,
Aleksandra Djokovic
(25)
,
Enrique Esteve-Valverde
(26)
,
Maria Favaro
(17)
,
Céline Fassot
(27, 28)
,
Raquel Ferrer-Oliveras
(6)
,
Alban Godon
(1)
,
Mohamed A. Hamidou
(29)
,
Milena Hasan
(30)
,
Daniel Henrion
(27, 28)
,
Bernard Imbert
(31)
,
Pierre Yves Jeandel
(32)
,
Pascale Jeannin
(1, 33)
,
Patrick Jego
(34)
,
Noemie Jourde-Chiche
(35, 36)
,
Jamilya Khizroeva
(37)
,
Olivier Lambotte
(38, 39)
,
Cédric Landron
(40)
,
Jose Omar Latino
(41)
,
Estibaliz Lazaro
(42)
,
Karina de Leeuw
(43)
,
Thomas Le Gallou
(34)
,
Levent Kiliç
(12)
,
Maarten Limper
(44)
,
Laurent Loufrani
(27, 28)
,
Romain Lubin
(27, 28)
,
Nadine Magy-Bertrand
(45)
,
Guillaume Mahé
(46, 34)
,
Alexander Makatsariya
(37)
,
Thierry Martin
(10)
,
Christian Muchardt
(47)
,
Gyorgy Nagy
,
Loukman Omarjee
(46, 34)
,
Pieter van Paasen
(48)
,
Gilles Pernod
(49)
,
Florence Perrinet
,
Gilberto Pïres Rosa
(50)
,
Marc Antoine Pistorius
(29)
,
Amelia Ruffatti
(17)
,
Fatma Said
(51)
,
Patrick Saulnier
(1)
,
Damien Sene
(52)
,
Loïc Sentilhes
(53)
,
Ova Shovman
(7)
,
Jean Sibilia
(54)
,
Crina Sinescu
(55)
,
Natasa Stanisavljevic
(25)
,
Ljudmila Stojanovich
(25)
,
Lai Shan Tam
(56)
,
Angela Tincani
(9)
,
Fréderic Tollis
(57)
,
Sebastian Udry
(41)
,
Marie Noelle Ungeheuer
(58)
,
Mathilde Versini
(59)
,
Ricard Cervera
(60)
,
Pier Luigi Meroni
(16)
1
CHU Angers -
Centre Hospitalier Universitaire d'Angers
2 BNMI - Biologie Neurovasculaire et Mitochondriale Intégrée
3 IRCCS - Istituto di Ricovero e Cura a Carattere Scientifico
4 UP13 - Université Paris 13
5 Hôpital Avicenne [AP-HP]
6 Vall d'Hebron University Hospital [Barcelona]
7 Sackler Faculty of Medicine
8 CHU Pitié-Salpêtrière [AP-HP]
9 UniBs - Università degli Studi di Brescia = University of Brescia
10 CHU Strasbourg - Centre Hospitalier Universitaire [Strasbourg]
11 UNICAEN - Université de Caen Normandie
12 Hacettepe University = Hacettepe Üniversitesi
13 Hôpital Saint-Joseph [Marseille]
14 Department of Obstetrics and Gynecology, I.M. Sechenow First Moscow State Medical University, Moscow, Russia.
15 ImmunoConcept - Immunology from Concept and Experiments to Translation = Immunologie Conceptuelle, Expérimentale et Translationnelle
16 IRCCS - Istituti di Ricovero e Cura a Carattere Scientifico
17 Unipd - Università degli Studi di Padova = University of Padua
18 University of Medicine and Pharmacy, Luliu-Hatieganu
19 Hôpital Européen [Fondation Ambroise Paré - Marseille]
20 Maastricht University [Maastricht]
21 University of Alberta
22 Universitatea Babeş-Bolyai [Cluj-Napoca]
23 Centre Hospitalier du Mans
24 Ghent University Hospital
25 University of Belgrade [Belgrade]
26 Althaia Healthcare Network of Manresa, Barcelona
27 MITOVASC - MitoVasc - Physiopathologie Cardiovasculaire et Mitochondriale
28 CARFI - Cardiovascular Functions In Vitro
29 CHU Nantes - Centre Hospitalier Universitaire de Nantes = Nantes University Hospital
30 CRT - Centre de Recherche Translationnelle - Center for Translational Science
31 CHUGA - Centre Hospitalier Universitaire [CHU Grenoble]
32 UNS - Université Nice Sophia Antipolis (1965 - 2019)
33 CRCNA - Centre de Recherche en Cancérologie Nantes-Angers
34 Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou]
35 VRCM - Vascular research center of Marseille
36 C2VN - Centre recherche en CardioVasculaire et Nutrition = Center for CardioVascular and Nutrition research
37 Department of Obstetrics and Gynecology, I.M. Sechenow First Moscow State Medical University, Moscow
38 IMVA - U1184 - Immunologie des Maladies Virales et Autoimmunes
39 Hôpital Bicêtre [AP-HP, Le Kremlin-Bicêtre]
40 CHU de Poitiers [La Milétrie] - Centre hospitalier universitaire de Poitiers = Poitiers University Hospital
41 Hospital Carlos G. Durand
42 Hôpital Haut-Lévêque [CHU Bordeaux]
43 UMCG - University Medical Center Groningen [Groningen]
44 UMCU - University Medical Center [Utrecht]
45 CHRU Besançon - Centre Hospitalier Régional Universitaire de Besançon
46 CIC - Centre d'Investigation Clinique [Rennes]
47 Cellules Souches et Développement / Stem Cells and Development
48 Semmelweis University [Budapest]
49 TIMC-IMAG - Techniques de l'Ingénierie Médicale et de la Complexité - Informatique, Mathématiques et Applications, Grenoble - UMR 5525
50 Hospital de São João [Porto]
51 Hôpital La Rabta [Tunis]
52 Hôpital Lariboisière
53 CHU Bordeaux - Centre Hospitalier Universitaire de Bordeaux
54 Service de rhumatologie [Strasbourg]
55 UMPCD - University of Medicine and Pharmacy “Carol Davila”
56 CUHK - The Chinese University of Hong Kong [Hong Kong]
57 Diaverum Dialysis Center, Angers
58 ICAReB - Investigation Clinique et d’Accès aux Ressources Biologiques (Plate-forme) - Clinical Investigation and Access to BioResources
59 Institut Arnault Tzanck
60 CRESIB - Barcelona Centre for International Health Research, Hospital Clinic
2 BNMI - Biologie Neurovasculaire et Mitochondriale Intégrée
3 IRCCS - Istituto di Ricovero e Cura a Carattere Scientifico
4 UP13 - Université Paris 13
5 Hôpital Avicenne [AP-HP]
6 Vall d'Hebron University Hospital [Barcelona]
7 Sackler Faculty of Medicine
8 CHU Pitié-Salpêtrière [AP-HP]
9 UniBs - Università degli Studi di Brescia = University of Brescia
10 CHU Strasbourg - Centre Hospitalier Universitaire [Strasbourg]
11 UNICAEN - Université de Caen Normandie
12 Hacettepe University = Hacettepe Üniversitesi
13 Hôpital Saint-Joseph [Marseille]
14 Department of Obstetrics and Gynecology, I.M. Sechenow First Moscow State Medical University, Moscow, Russia.
15 ImmunoConcept - Immunology from Concept and Experiments to Translation = Immunologie Conceptuelle, Expérimentale et Translationnelle
16 IRCCS - Istituti di Ricovero e Cura a Carattere Scientifico
17 Unipd - Università degli Studi di Padova = University of Padua
18 University of Medicine and Pharmacy, Luliu-Hatieganu
19 Hôpital Européen [Fondation Ambroise Paré - Marseille]
20 Maastricht University [Maastricht]
21 University of Alberta
22 Universitatea Babeş-Bolyai [Cluj-Napoca]
23 Centre Hospitalier du Mans
24 Ghent University Hospital
25 University of Belgrade [Belgrade]
26 Althaia Healthcare Network of Manresa, Barcelona
27 MITOVASC - MitoVasc - Physiopathologie Cardiovasculaire et Mitochondriale
28 CARFI - Cardiovascular Functions In Vitro
29 CHU Nantes - Centre Hospitalier Universitaire de Nantes = Nantes University Hospital
30 CRT - Centre de Recherche Translationnelle - Center for Translational Science
31 CHUGA - Centre Hospitalier Universitaire [CHU Grenoble]
32 UNS - Université Nice Sophia Antipolis (1965 - 2019)
33 CRCNA - Centre de Recherche en Cancérologie Nantes-Angers
34 Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou]
35 VRCM - Vascular research center of Marseille
36 C2VN - Centre recherche en CardioVasculaire et Nutrition = Center for CardioVascular and Nutrition research
37 Department of Obstetrics and Gynecology, I.M. Sechenow First Moscow State Medical University, Moscow
38 IMVA - U1184 - Immunologie des Maladies Virales et Autoimmunes
39 Hôpital Bicêtre [AP-HP, Le Kremlin-Bicêtre]
40 CHU de Poitiers [La Milétrie] - Centre hospitalier universitaire de Poitiers = Poitiers University Hospital
41 Hospital Carlos G. Durand
42 Hôpital Haut-Lévêque [CHU Bordeaux]
43 UMCG - University Medical Center Groningen [Groningen]
44 UMCU - University Medical Center [Utrecht]
45 CHRU Besançon - Centre Hospitalier Régional Universitaire de Besançon
46 CIC - Centre d'Investigation Clinique [Rennes]
47 Cellules Souches et Développement / Stem Cells and Development
48 Semmelweis University [Budapest]
49 TIMC-IMAG - Techniques de l'Ingénierie Médicale et de la Complexité - Informatique, Mathématiques et Applications, Grenoble - UMR 5525
50 Hospital de São João [Porto]
51 Hôpital La Rabta [Tunis]
52 Hôpital Lariboisière
53 CHU Bordeaux - Centre Hospitalier Universitaire de Bordeaux
54 Service de rhumatologie [Strasbourg]
55 UMPCD - University of Medicine and Pharmacy “Carol Davila”
56 CUHK - The Chinese University of Hong Kong [Hong Kong]
57 Diaverum Dialysis Center, Angers
58 ICAReB - Investigation Clinique et d’Accès aux Ressources Biologiques (Plate-forme) - Clinical Investigation and Access to BioResources
59 Institut Arnault Tzanck
60 CRESIB - Barcelona Centre for International Health Research, Hospital Clinic
Cristina Belizna
- Fonction : Auteur correspondant
Sébastien Abad
- Fonction : Auteur
- PersonId : 774635
- IdRef : 184462436
Howard Amital
- Fonction : Auteur
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- ORCID : 0000-0002-5406-7716
Laurent Arnaud
- Fonction : Auteur
- PersonId : 735667
- IdHAL : laurent-arnaud
- ORCID : 0000-0002-4432-4205
- IdRef : 026691019
Patrick Blanco
- Fonction : Auteur
- PersonId : 756121
- ORCID : 0000-0002-5374-3639
Jan Willem Cohen Tervaert
- Fonction : Auteur
Céline Fassot
- Fonction : Auteur
- PersonId : 182717
- IdHAL : celine-fassot
- ORCID : 0000-0003-0145-8411
- IdRef : 241982189
Milena Hasan
- Fonction : Auteur
- PersonId : 749483
- IdHAL : milena-hasan
- ORCID : 0000-0002-0879-7099
Daniel Henrion
- Fonction : Auteur
- PersonId : 178861
- IdHAL : daniel-henrion
- ORCID : 0000-0003-1094-0285
- IdRef : 092696252
Noemie Jourde-Chiche
- Fonction : Auteur
- PersonId : 803126
- ORCID : 0000-0001-9315-1577
- IdRef : 118722352
Estibaliz Lazaro
- Fonction : Auteur
- PersonId : 756120
- ORCID : 0000-0002-4206-7399
Laurent Loufrani
- Fonction : Auteur
- PersonId : 738906
- IdHAL : laurent-loufrani
- ORCID : 0000-0003-3397-2335
- IdRef : 191329398
Thierry Martin
- Fonction : Auteur
- PersonId : 183399
- IdHAL : thierrymartin105
- ORCID : 0000-0001-8320-7055
Christian Muchardt
- Fonction : Auteur
- PersonId : 740091
- IdHAL : muchardt
- ORCID : 0000-0003-0145-4023
- IdRef : 111170133
Gyorgy Nagy
- Fonction : Auteur
Florence Perrinet
- Fonction : Auteur
Résumé
The relapse rate in antiphospholipid syndrome (APS) remains high, i.e. around 20%–21% at 5 years in thrombotic APS and 20–28% in obstetrical APS [2, 3].Hydroxychloroquine (HCQ) appears as an additional therapy, as it possesses immunomodulatory and anti-thrombotic various effects [4–16].Our group recently obtained the orphan designation of HCQ in antiphospholipid syndrome by the European Medicine Agency.Furthermore, the leaders of the project made the proposal of an international project, HIBISCUS, about the use of Hydroxychloroquine in secondary prevention of obstetrical and thrombotic events in primary APS. This study has been launched in several countries and at now, 53 centers from 16 countries participate to this international trial.This trial consists in two parts: a retrospective and a prospective study.The French part of the trial in thrombosis has been granted by the French Minister of Health in December 2015 (the academic trial independent of the pharmaceutical industry PHRC N PAPIRUS) and is coordinated by one of the members of the leading consortium of HIBISCUS.