%0 Journal Article %T Determinants of 20-year non-progression to Type 2 diabetes in women at very high risk: the E3N cohort study %+ Centre de recherche en épidémiologie et santé des populations (CESP) %+ CHU Pontchaillou [Rennes] %+ Université de Rennes (UR) %A Fagherazzi, Guy %A Gusto, G. %A Mancini, F., R. %A Dow, C. %A Rajaobelina, K. %A Balkau, Beverley %A Boutron-Ruault, M.-C. %A Bonnet, F. %Z The E3N cohort is being carried out with the financial support of the Mutuelle Générale de l'Education Nationale, the European Community, French League against Cancer, Gustave Roussy, and the French Institute of Health and Medical Research. The present study was also supported by the French Research Agency (Agence Nationale de la Recherche) via an Investissement d'Avenir (investment for the future) grant (ANR‐10‐COHO‐0006) that supports the E4N study, and the IDEX Paris Saclay (Nutriperso project). %< avec comité de lecture %@ 0742-3071 %J Diabetic Medicine %I Wiley %8 2018 %D 2018 %R 10.1111/dme.13774 %Z Life Sciences [q-bio] %Z Life Sciences [q-bio]/Human health and pathology/Endocrinology and metabolismJournal articles %X AimsTo identify the most important determinants associated with not developing Type 2 diabetes in women considered to be at very high risk.MethodsBetween 1995 and 2014, we followed 402 women from the E3N cohort study who were considered to be at very high risk of Type 2 diabetes based on the D.E.S.I.R. score. We then computed a classification and regression tree model to identify, among a large set of risk factors, the top risk factors associated with not having Type 2 diabetes at the end of the follow‐up.ResultsDuring follow‐up, 117 women (29%) were diagnosed with Type 2 diabetes, while 285 (71%) were still free of the disease in 2014. A low Western dietary pattern score was the top characteristic associated with not developing Type 2 diabetes, as only 20% of the women at very high risk in the E3N study with that characteristic developed Type 2 diabetes (compared with 29% overall). In women with a moderate or high Western dietary pattern score, the most important characteristic associated with not developing Type 2 diabetes was a high total dietary antioxidant capacity, as only 26% of these women ultimately developed Type 2 diabetes.ConclusionsWe showed that the top characteristic associated with not developing Type 2 diabetes, despite being at very high risk, was a healthy diet, characterized by limiting Western dietary habits, but with a high intake of antioxidant‐rich foods. This underscores the importance of diet in the prevention of Type 2 diabetes in people at high risk. %G English %2 https://univ-rennes.hal.science/hal-01928156/document %2 https://univ-rennes.hal.science/hal-01928156/file/Fagherazzi%20et%20al_Determinants%20of%2020-year%20non-progression%20to%20Type%202%20diabetes%20in%20women.pdf %L hal-01928156 %U https://univ-rennes.hal.science/hal-01928156 %~ UNIV-RENNES1 %~ UNIV-PSUD %~ APHP %~ E3N %~ HL %~ UVSQ %~ STATS-UR1 %~ UR1-HAL %~ INSERM-SACLAY %~ UNIV-PARIS-SACLAY %~ UNIV-PSUD-SACLAY %~ UVSQ-SACLAY %~ TEST-UR-CSS %~ UNIV-RENNES %~ UVSQ-UPSACLAY %~ ANR %~ GS-SANTE-PUBLIQUE