Synthesis of (Poly)halo-substituted Diarylsulfones through Palladium Catalyzed C-H Bond Sulfonylation using (Poly)Halobenzenesulfonyl Chlorides - Université de Rennes Accéder directement au contenu
Article Dans Une Revue European Journal of Organic Chemistry Année : 2018

Synthesis of (Poly)halo-substituted Diarylsulfones through Palladium Catalyzed C-H Bond Sulfonylation using (Poly)Halobenzenesulfonyl Chlorides

Résumé

The reactivity of (poly)halo-substituted benzenesulfonyl chlorides in palladium-catalyzed ortho-directed C-H bond sulfonylation of 2-arylpyridines was investigated. The use of Ag2CO3 in concert with Cu(OAc)2 was found to be critical to promote the chemoselective sulfonylation reaction. Fluoro-, chloro-, bromo-, and even iodo-benzenesulfonyl chlorides react nicely to afford halo-substituted diarylsulfones in good to high yields without cleavage of the C-halo bonds, allowing further transformations.
Fichier principal
Vignette du fichier
Sasmal et al_Synthesis of (Poly)halo-substituted Diarylsulfones through Palladium Catalyzed.pdf (817.15 Ko) Télécharger le fichier
Origine : Fichiers produits par l'(les) auteur(s)
Loading...

Dates et versions

hal-01915420 , version 1 (07-11-2018)

Identifiants

Citer

Arpan Sasmal, Jitendra K. Bera, Henri Doucet, Jean-François Soulé. Synthesis of (Poly)halo-substituted Diarylsulfones through Palladium Catalyzed C-H Bond Sulfonylation using (Poly)Halobenzenesulfonyl Chlorides. European Journal of Organic Chemistry, 2018, 2018 (44), pp.6114-6120. ⟨10.1002/ejoc.201800819⟩. ⟨hal-01915420⟩
43 Consultations
117 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More