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Article Dans Une Revue Molecules Année : 2018

tert-Butylphenolic Derivatives from Paenibacillus odorifer-A Case of Bioconversion

Résumé

Two compounds () and () containing -butylphenol groups were, for the first time, produced during the culture of , a bacterial strain associated with the crustose lichen, . Their entire structures were identified by one-dimensional (1D) and two-dimensional (2D) NMR and high-resolution electrospray ionisation mass spectrometry (HRESIMS) spectroscopic analyses. Among them, Compound exhibited significant cytotoxicity against B16 murine melanoma and HaCaT human keratinocyte cell lines with micromolar half maximal inhibitory concentration (IC) values. Furthermore, after supplementation studies, a putative biosynthesis pathway was proposed for Compound throughout a bioconversion by this bacterial strain of butylated hydroxyanisole (BHA), an antioxidant polymer additive.

Domaines

Biotechnologies
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Dates et versions

hal-01862458 , version 1 (03-10-2018)

Identifiants

Citer

Thi-Bach-Le Nguyen, Olivier Delalande, Isabelle Rouaud, Solenn Ferron, Laura Chaillot, et al.. tert-Butylphenolic Derivatives from Paenibacillus odorifer-A Case of Bioconversion. Molecules, 2018, 23 (8), pp.1951. ⟨10.3390/molecules23081951⟩. ⟨hal-01862458⟩
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