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Journal Articles Transcription Year : 2018

Reading cytosine modifications within chromatin


Zinc-finger and homeodomain transcription factors have been shown in vitro to bind to recognition motifs containing a methylated CpG. However, accessing these motifs in vivo might be seriously impeded by the inclusion of DNA in nucleosomes and by the condensed structure adopted by chromatin formed on methylated DNA. Here, we discuss how oxidation of 5-methylcytosine into 5-hydroxymethylcytosine could provide the initial destabilizing clue for such transcription factors to get access to nucleosomal DNA and read epigenetic information.

Dates and versions

hal-01812520 , version 1 (11-06-2018)



Elise A Mahé, Thierry Madigou, Gilles Salbert. Reading cytosine modifications within chromatin. Transcription, 2018, 9 (4), pp.240-247. ⟨10.1080/21541264.2017.1406435⟩. ⟨hal-01812520⟩
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