%0 Journal Article %T Manganese catalyzed reductive amination of aldehydes using hydrogen as a reductant %+ Institut des Sciences Chimiques de Rennes (ISCR) %+ Laboratoire de chimie de coordination (LCC) %+ Institut Universitaire de France (IUF) %A Wei, Duo %A Bruneau-Voisine, Antoine %A Valyaev, Dmitry, A. %A Lugan, Noël %A Sortais, Jean-Baptiste %Z Centre National de la Recherche Scientifique %Z Institut Universitaire de France %Z ANR-15-CE07-0001, Agence Nationale de la Recherche %< avec comité de lecture %@ 1359-7345 %J Chemical Communications %I Royal Society of Chemistry %V 54 %N 34 %P 4302-4305 %8 2018-04-24 %D 2018 %R 10.1039/C8CC01787E %M 29633769 %Z Chemical Sciences %Z Chemical Sciences/Organic chemistryJournal articles %X A one-pot two-step procedure was developed for the alkylation of amines via reductive amination of aldehydes using molecular dihydrogen as a reductant in the presence of a manganese pyridinyl-phosphine complex as a pre-catalyst. After the initial condensation step, the reduction of imines formed in situ is performed under mild conditions (50-100 degrees C) with 2 mol% of catalyst and 5 mol% of tBuOK under 50 bar of hydrogen. Excellent yields (>90%) were obtained for a large combination of aldehydes and amines (40 examples), including aliphatic aldehydes and amino-alcohols. %G English %2 https://univ-rennes.hal.science/hal-01807069/document %2 https://univ-rennes.hal.science/hal-01807069/file/Wei%20-%20Duo_reductive_amination_cc_no_highlight.pdf %L hal-01807069 %U https://univ-rennes.hal.science/hal-01807069 %~ IRD %~ UNIV-TLSE3 %~ UNIV-RENNES1 %~ CNRS %~ INSA-RENNES %~ ENSC-RENNES %~ ISCR %~ SCR_OMC2012 %~ LCC %~ STATS-UR1 %~ UR1-SPM %~ INC-CNRS %~ UR1-UFR-SPM %~ UR1-HAL %~ UR1-SDLM %~ TEST-UR-CSS %~ UNIV-RENNES %~ INSA-GROUPE %~ TEST-HALCNRS %~ ANR %~ UR1-MMS %~ TOULOUSE-INP %~ UNIV-UT3 %~ UT3-INP %~ UT3-TOULOUSEINP %~ TEST2-HALCNRS %~ TEST3-HALCNRS