Manganese catalyzed reductive amination of aldehydes using hydrogen as a reductant - Université de Rennes Access content directly
Journal Articles Chemical Communications Year : 2018

Manganese catalyzed reductive amination of aldehydes using hydrogen as a reductant

Abstract

A one-pot two-step procedure was developed for the alkylation of amines via reductive amination of aldehydes using molecular dihydrogen as a reductant in the presence of a manganese pyridinyl-phosphine complex as a pre-catalyst. After the initial condensation step, the reduction of imines formed in situ is performed under mild conditions (50-100 degrees C) with 2 mol% of catalyst and 5 mol% of tBuOK under 50 bar of hydrogen. Excellent yields (>90%) were obtained for a large combination of aldehydes and amines (40 examples), including aliphatic aldehydes and amino-alcohols.
Fichier principal
Vignette du fichier
Wei - Duo_reductive_amination_cc_no_highlight.pdf (1.02 Mo) Télécharger le fichier
Origin : Files produced by the author(s)
Loading...

Dates and versions

hal-01807069 , version 1 (20-06-2018)

Identifiers

Cite

Duo Wei, Antoine Bruneau-Voisine, Dmitry A. Valyaev, Noël Lugan, Jean-Baptiste Sortais. Manganese catalyzed reductive amination of aldehydes using hydrogen as a reductant. Chemical Communications, 2018, 54 (34), pp.4302-4305. ⟨10.1039/C8CC01787E⟩. ⟨hal-01807069⟩
68 View
318 Download

Altmetric

Share

Gmail Facebook X LinkedIn More