%0 Journal Article %T Prognostic value of serum CYFRA 21-1 1 in patients with anal canal squamous cell carcinoma treated with radio(chemo)therapy %+ Institut Curie [Paris] %+ CHU Tenon [AP-HP] %+ Chemistry, Oncogenesis, Stress and Signaling (COSS) %+ CHU Pontchaillou [Rennes] %+ Unité de Technologies Chimiques et Biologiques pour la Santé (UTCBS - UM 4 (UMR 8258 / U1022)) %+ Université de Rennes - Faculté de Médecine (UR Médecine) %A Gauthé, Mathieu %A Richard-Molard, Marion %A Rigault, Eugénie %A Buecher, Bruno %A Mariani, Pascale %A Bellet, Dominique %A Cacheux, Wulfran %A Lièvre, Astrid %< avec comité de lecture %@ 1471-2407 %J BMC Cancer %I BioMed Central %V 18 %N 1 %P 417 %8 2018 %D 2018 %R 10.1186/s12885-018-4335-4 %M 29653564 %K CYFRA 21-1 %K Anal carcinoma %K Prognosis %K Recurrence %K Tumour marker %Z Life Sciences [q-bio]/Cancer %Z Chemical SciencesJournal articles %X Background - We aimed to assess the prognostic value of CYFRA 21-1 in a series of patients with anal canal squamous cell carcinoma treated by radiation-based therapy. Methods - All patients with anal cancer referred between September 2005 and July 2013 were considered. Patients with diagnosis of anal squamous cell carcinoma and in whom pre- and post-treatment serum CYFRA 21-1 levels were available were included. Serum CYFRA 21-1 levels at initial workup and after therapy were collected. Survival rates were estimated using the Kaplan-Meier method. Cox regression analysis was used to evaluate prognostic variables for prediction of outcomes. Results - Eighty-two patients were included. Median follow-up was 60 months (range: 8-128). Pre-treatment serum CYFRA 21-1 levels were significantly correlated with tumour stage (p < 0.001). Normal post-treatment serum CYFRA 21-1 level was significantly correlated with tumour complete response (p = 0.004). Elevated post-treatment serum CYFRA 21-1 level was significantly associated with poorer progression-free survival (p = 0.02) and overall survival (p = 0.003). T stage and post-treatment serum CYFRA 21-1 were independent prognostic factors for overall survival (p = 0.04 and 0.03, respectively). Conclusions - Serum CYFRA 21-1 appears to be a useful marker for the monitoring of anal squamous cell carcinoma patients. Elevated post-treatment value appears to be correlated with treatment failure. %G English %2 https://univ-rennes.hal.science/hal-01778378/document %2 https://univ-rennes.hal.science/hal-01778378/file/s12885-018-4335-4 %L hal-01778378 %U https://univ-rennes.hal.science/hal-01778378 %~ INSERM %~ UNIV-PARIS5 %~ ENSCP %~ UNIV-RENNES1 %~ CNRS %~ ENSC-PARIS %~ APHP %~ PARISTECH %~ FNCLCC %~ CURIE %~ MARQUIS %~ HL %~ STATS-UR1 %~ OSS %~ INC-CNRS %~ UR1-UFR-SVE %~ UR1-HAL %~ PSL %~ USPC %~ UR1-SDV %~ TEST-UR-CSS %~ UNIV-RENNES %~ SORBONNE-UNIVERSITE %~ SORBONNE-UNIV %~ SU-MEDECINE %~ SU-MED %~ UNIV-PARIS %~ UP-SANTE %~ TEST-HALCNRS %~ ENSCP-PSL %~ INSTITUT-CURIE-PSL %~ SU-TI %~ UR1-BIO-SA %~ UTCBS %~ ALLIANCE-SU %~ TEST2-HALCNRS %~ TEST3-HALCNRS