<?xml version="1.0" encoding="utf-8"?>
<TEI xmlns="http://www.tei-c.org/ns/1.0" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:hal="http://hal.archives-ouvertes.fr/" xmlns:gml="http://www.opengis.net/gml/3.3/" xmlns:gmlce="http://www.opengis.net/gml/3.3/ce" version="1.1" xsi:schemaLocation="http://www.tei-c.org/ns/1.0 http://api.archives-ouvertes.fr/documents/aofr-sword.xsd">
  <teiHeader>
    <fileDesc>
      <titleStmt>
        <title>HAL TEI export of hal-01744446</title>
      </titleStmt>
      <publicationStmt>
        <distributor>CCSD</distributor>
        <availability status="restricted">
          <licence target="https://creativecommons.org/publicdomain/zero/1.0/">CC0 1.0 - Universal</licence>
        </availability>
        <date when="2026-05-24T10:05:12+02:00"/>
      </publicationStmt>
      <sourceDesc>
        <p part="N">HAL API Platform</p>
      </sourceDesc>
    </fileDesc>
  </teiHeader>
  <text>
    <body>
      <listBibl>
        <biblFull>
          <titleStmt>
            <title xml:lang="en">Pregnancy Outcomes after ZIKV Infection in French Territories in the Americas</title>
            <author role="aut">
              <persName>
                <forename type="first">Bruno</forename>
                <surname>Hoen</surname>
              </persName>
              <email type="md5">c22945bbb01a9e61cae2dff70575e042</email>
              <email type="domain">univ-fcomte.fr</email>
              <idno type="idhal" notation="string">bruno-hoen</idno>
              <idno type="idhal" notation="numeric">11357</idno>
              <idno type="halauthorid" notation="string">7785-11357</idno>
              <idno type="ORCID">https://orcid.org/0000-0003-3070-3017</idno>
              <idno type="IDREF">https://www.idref.fr/058486194</idno>
              <affiliation ref="#struct-328176"/>
              <affiliation ref="#struct-171463"/>
              <affiliation ref="#struct-93016"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Bruno</forename>
                <surname>Schaub</surname>
              </persName>
              <idno type="halauthorid">1144921-0</idno>
              <affiliation ref="#struct-363873"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Anna L</forename>
                <surname>Funk</surname>
              </persName>
              <idno type="halauthorid">1334391-0</idno>
              <affiliation ref="#struct-31480"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Vanessa</forename>
                <surname>Ardillon</surname>
              </persName>
              <idno type="halauthorid">549928-0</idno>
              <affiliation ref="#struct-461591"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Manon</forename>
                <surname>Boullard</surname>
              </persName>
              <idno type="halauthorid">1334392-0</idno>
              <affiliation ref="#struct-171463"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">André</forename>
                <surname>Cabié</surname>
              </persName>
              <email type="md5">2814377ef513f067317022aee9d42864</email>
              <email type="domain">chu-fortdefrance.fr</email>
              <idno type="idhal" notation="string">andre-cabie</idno>
              <idno type="idhal" notation="numeric">11222</idno>
              <idno type="halauthorid" notation="string">32573-11222</idno>
              <idno type="ORCID">https://orcid.org/0000-0003-0117-3061</idno>
              <idno type="IDREF">https://www.idref.fr/08145094X</idno>
              <affiliation ref="#struct-171463"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Caroline</forename>
                <surname>Callier</surname>
              </persName>
              <idno type="halauthorid">1334393-0</idno>
              <affiliation ref="#struct-171463"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Gabriel</forename>
                <surname>Carles</surname>
              </persName>
              <idno type="halauthorid">788065-0</idno>
              <affiliation ref="#struct-487342"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Sylvie</forename>
                <surname>Cassadou</surname>
              </persName>
              <idno type="halauthorid">689853-0</idno>
              <affiliation ref="#struct-461591"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Raymond</forename>
                <surname>Césaire</surname>
              </persName>
              <idno type="halauthorid">162927-0</idno>
              <affiliation ref="#struct-494317"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Maylis</forename>
                <surname>Douine</surname>
              </persName>
              <email type="md5">452eb76621de63f2a020e1876573228e</email>
              <email type="domain">ch-cayenne.fr</email>
              <idno type="idhal" notation="numeric">772327</idno>
              <idno type="halauthorid" notation="string">860591-772327</idno>
              <idno type="ORCID">https://orcid.org/0000-0003-4616-6690</idno>
              <idno type="IDREF">https://www.idref.fr/134571533</idno>
              <affiliation ref="#struct-171463"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Cécile</forename>
                <surname>Herrmann-Storck</surname>
              </persName>
              <idno type="halauthorid">1168452-0</idno>
              <affiliation ref="#struct-328176"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Philippe</forename>
                <surname>Kadhel</surname>
              </persName>
              <idno type="halauthorid">480117-0</idno>
              <affiliation ref="#struct-328176"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Cédric</forename>
                <surname>Laouénan</surname>
              </persName>
              <idno type="idhal" notation="numeric">771320</idno>
              <idno type="halauthorid" notation="string">709802-771320</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-3681-6314</idno>
              <idno type="IDREF">https://www.idref.fr/138946159</idno>
              <affiliation ref="#struct-247341"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Yoann</forename>
                <surname>Madec</surname>
              </persName>
              <email type="md5">1b0e28c03e06f2b3d100970d7c714029</email>
              <email type="domain">pasteur.fr</email>
              <idno type="idhal" notation="string">yoann-madec</idno>
              <idno type="idhal" notation="numeric">734914</idno>
              <idno type="halauthorid" notation="string">2524226-734914</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-6201-1261</idno>
              <affiliation ref="#struct-31480"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Alice</forename>
                <surname>Monthieux</surname>
              </persName>
              <idno type="halauthorid">990126-0</idno>
              <affiliation ref="#struct-420321"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Mathieu</forename>
                <surname>Nacher</surname>
              </persName>
              <email type="md5">448f23025d0c0875fe64008bd4d6e303</email>
              <email type="domain">gmail.com</email>
              <idno type="idhal" notation="string">mathieu-nacher</idno>
              <idno type="idhal" notation="numeric">11286</idno>
              <idno type="halauthorid" notation="string">19684-11286</idno>
              <idno type="ORCID">https://orcid.org/0000-0001-9397-3204</idno>
              <idno type="IDREF">https://www.idref.fr/087955512</idno>
              <affiliation ref="#struct-171463"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Fatiha</forename>
                <surname>Najioullah</surname>
              </persName>
              <email type="md5">23314559be47ccb30ea359de0dd52940</email>
              <email type="domain">chu-martinique.fr</email>
              <idno type="idhal" notation="numeric">1290430</idno>
              <idno type="halauthorid" notation="string">471565-1290430</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-2922-1400</idno>
              <affiliation ref="#struct-494317"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Dominique</forename>
                <surname>Rousset</surname>
              </persName>
              <email type="md5">43b50d741efa4204f090a1aeb7b63e08</email>
              <email type="domain">pasteur.fr</email>
              <idno type="idhal" notation="string">dominique-rousset211</idno>
              <idno type="idhal" notation="numeric">185062</idno>
              <idno type="halauthorid" notation="string">43761-185062</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-1473-3147</idno>
              <idno type="IDREF">https://www.idref.fr/224013033</idno>
              <affiliation ref="#struct-300193"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Catherine</forename>
                <surname>Ryan</surname>
              </persName>
              <idno type="halauthorid">1021551-0</idno>
              <affiliation ref="#struct-328176"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Kinda</forename>
                <surname>Schepers</surname>
              </persName>
              <idno type="halauthorid">1064673-0</idno>
              <affiliation ref="#struct-503020"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Sofia</forename>
                <surname>Stegmann-Planchard</surname>
              </persName>
              <idno type="halauthorid">1334394-0</idno>
              <affiliation ref="#struct-1196168"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Benoît</forename>
                <surname>Tressières</surname>
              </persName>
              <idno type="halauthorid">719283-0</idno>
              <affiliation ref="#struct-171463"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Jean-Luc</forename>
                <surname>Voluménie</surname>
              </persName>
              <idno type="halauthorid">1334395-0</idno>
              <affiliation ref="#struct-363873"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Samson</forename>
                <surname>Yassinguezo</surname>
              </persName>
              <idno type="halauthorid">1334396-0</idno>
              <affiliation ref="#struct-494314"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Eustase</forename>
                <surname>Janky</surname>
              </persName>
              <idno type="halauthorid">480118-0</idno>
              <affiliation ref="#struct-328176"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Arnaud</forename>
                <surname>Fontanet</surname>
              </persName>
              <email type="md5">c75d171698d20a4c4f2f1c57dac264a5</email>
              <email type="domain">pasteur.fr</email>
              <idno type="idhal" notation="numeric">1584871</idno>
              <idno type="halauthorid" notation="string">158599-1584871</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-5239-6110</idno>
              <affiliation ref="#struct-31480"/>
              <affiliation ref="#struct-484404"/>
              <affiliation ref="#struct-300351"/>
            </author>
            <editor role="depositor">
              <persName>
                <forename>Laurent</forename>
                <surname>Jonchère</surname>
              </persName>
              <email type="md5">dc1f1e9bdb3dc2065f8bf1bfd5663118</email>
              <email type="domain">univ-rennes.fr</email>
            </editor>
            <funder ref="#projanr-24021"/>
            <funder>Supported by the French Ministry of Health (Soutien Exceptionnel à la Recherche et à l’Innovation), by a grant (ANR-10-LABX-62-IBEID) from Laboratoire d’Excellence Integrative Biology of Emerging Infectious Diseases project, by the ZIKAlliance consortium (the European Union’s Horizon 2020 Research and Innovation Program), and by INSERM. This study is part of the ZIKAlliance consortium project.</funder>
          </titleStmt>
          <editionStmt>
            <edition n="v1" type="current">
              <date type="whenSubmitted">2018-04-16 14:33:21</date>
              <date type="whenModified">2025-09-29 11:40:13</date>
              <date type="whenReleased">2018-04-16 14:33:22</date>
              <date type="whenProduced">2018-03-15</date>
              <ref type="externalLink" target="https://doi.org/10.1056/nejmoa1709481"/>
            </edition>
            <respStmt>
              <resp>contributor</resp>
              <name key="113861">
                <persName>
                  <forename>Laurent</forename>
                  <surname>Jonchère</surname>
                </persName>
                <email type="md5">dc1f1e9bdb3dc2065f8bf1bfd5663118</email>
                <email type="domain">univ-rennes.fr</email>
              </name>
            </respStmt>
          </editionStmt>
          <publicationStmt>
            <distributor>CCSD</distributor>
            <idno type="halId">hal-01744446</idno>
            <idno type="halUri">https://univ-rennes.hal.science/hal-01744446</idno>
            <idno type="halBibtex">hoen:hal-01744446</idno>
            <idno type="halRefHtml">&lt;i&gt;New England Journal of Medicine&lt;/i&gt;, 2018, 378 (11), pp.985-994. &lt;a target="_blank" href="https://dx.doi.org/10.1056/NEJMoa1709481"&gt;&amp;#x27E8;10.1056/NEJMoa1709481&amp;#x27E9;&lt;/a&gt;</idno>
            <idno type="halRef">New England Journal of Medicine, 2018, 378 (11), pp.985-994. &amp;#x27E8;10.1056/NEJMoa1709481&amp;#x27E9;</idno>
            <availability status="restricted"/>
          </publicationStmt>
          <seriesStmt>
            <idno type="stamp" n="INSERM">INSERM - Institut national de la santé et de la recherche médicale</idno>
            <idno type="stamp" n="PASTEUR">Institut Pasteur</idno>
            <idno type="stamp" n="UNIV-PARIS7" corresp="UNIV-PARIS">Université Denis Diderot - Paris VII</idno>
            <idno type="stamp" n="RIIP">Pasteur Network</idno>
            <idno type="stamp" n="UNIV-PARIS13">Université Paris-Nord - Paris XIII </idno>
            <idno type="stamp" n="UNIV-AG">Université des Antilles</idno>
            <idno type="stamp" n="CNAM">Conservatoire National des Arts et Métiers</idno>
            <idno type="stamp" n="RIIP_GUYANE" corresp="RIIP">Institut Pasteur de la Guyane</idno>
            <idno type="stamp" n="USPC">Université Sorbonne Paris Cité</idno>
            <idno type="stamp" n="IAME" corresp="UNIV-PARIS13">Infection, Anti-microbiens, Modélisation, Evolution - UMR 1137</idno>
            <idno type="stamp" n="UNIV-RENNES">Université de Rennes</idno>
            <idno type="stamp" n="SORBONNE-PARIS-NORD">Université Sorbonne Paris Nord</idno>
            <idno type="stamp" n="MAITC" corresp="UNIV-AG">Maladies Infectieuses et Tropicales dans la Caraïbe [EA 4537]</idno>
            <idno type="stamp" n="UNIV-PARIS">Université Paris Cité</idno>
            <idno type="stamp" n="UP-SANTE">Université Paris Cité - Faculté de Santé</idno>
            <idno type="stamp" n="ANR">ANR</idno>
            <idno type="stamp" n="TEST3-HALCNRS">TEST3-HALCNRS</idno>
            <idno type="stamp" n="ACT-R" corresp="UNIV-PARIS13">Act'R </idno>
            <idno type="stamp" n="HESAM-CNAM" corresp="HESAM">Conservatoire National des Arts et Métiers - Hesam</idno>
            <idno type="stamp" n="HESAM">Hesam</idno>
            <idno type="stamp" n="SANTEPUBLIQUEFRANCE">Santé publique France</idno>
          </seriesStmt>
          <notesStmt>
            <note type="audience" n="2">International</note>
            <note type="popular" n="0">No</note>
            <note type="peer" n="1">Yes</note>
          </notesStmt>
          <sourceDesc>
            <biblStruct>
              <analytic>
                <title xml:lang="en">Pregnancy Outcomes after ZIKV Infection in French Territories in the Americas</title>
                <author role="aut">
                  <persName>
                    <forename type="first">Bruno</forename>
                    <surname>Hoen</surname>
                  </persName>
                  <email type="md5">c22945bbb01a9e61cae2dff70575e042</email>
                  <email type="domain">univ-fcomte.fr</email>
                  <idno type="idhal" notation="string">bruno-hoen</idno>
                  <idno type="idhal" notation="numeric">11357</idno>
                  <idno type="halauthorid" notation="string">7785-11357</idno>
                  <idno type="ORCID">https://orcid.org/0000-0003-3070-3017</idno>
                  <idno type="IDREF">https://www.idref.fr/058486194</idno>
                  <affiliation ref="#struct-328176"/>
                  <affiliation ref="#struct-171463"/>
                  <affiliation ref="#struct-93016"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Bruno</forename>
                    <surname>Schaub</surname>
                  </persName>
                  <idno type="halauthorid">1144921-0</idno>
                  <affiliation ref="#struct-363873"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Anna L</forename>
                    <surname>Funk</surname>
                  </persName>
                  <idno type="halauthorid">1334391-0</idno>
                  <affiliation ref="#struct-31480"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Vanessa</forename>
                    <surname>Ardillon</surname>
                  </persName>
                  <idno type="halauthorid">549928-0</idno>
                  <affiliation ref="#struct-461591"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Manon</forename>
                    <surname>Boullard</surname>
                  </persName>
                  <idno type="halauthorid">1334392-0</idno>
                  <affiliation ref="#struct-171463"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">André</forename>
                    <surname>Cabié</surname>
                  </persName>
                  <email type="md5">2814377ef513f067317022aee9d42864</email>
                  <email type="domain">chu-fortdefrance.fr</email>
                  <idno type="idhal" notation="string">andre-cabie</idno>
                  <idno type="idhal" notation="numeric">11222</idno>
                  <idno type="halauthorid" notation="string">32573-11222</idno>
                  <idno type="ORCID">https://orcid.org/0000-0003-0117-3061</idno>
                  <idno type="IDREF">https://www.idref.fr/08145094X</idno>
                  <affiliation ref="#struct-171463"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Caroline</forename>
                    <surname>Callier</surname>
                  </persName>
                  <idno type="halauthorid">1334393-0</idno>
                  <affiliation ref="#struct-171463"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Gabriel</forename>
                    <surname>Carles</surname>
                  </persName>
                  <idno type="halauthorid">788065-0</idno>
                  <affiliation ref="#struct-487342"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Sylvie</forename>
                    <surname>Cassadou</surname>
                  </persName>
                  <idno type="halauthorid">689853-0</idno>
                  <affiliation ref="#struct-461591"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Raymond</forename>
                    <surname>Césaire</surname>
                  </persName>
                  <idno type="halauthorid">162927-0</idno>
                  <affiliation ref="#struct-494317"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Maylis</forename>
                    <surname>Douine</surname>
                  </persName>
                  <email type="md5">452eb76621de63f2a020e1876573228e</email>
                  <email type="domain">ch-cayenne.fr</email>
                  <idno type="idhal" notation="numeric">772327</idno>
                  <idno type="halauthorid" notation="string">860591-772327</idno>
                  <idno type="ORCID">https://orcid.org/0000-0003-4616-6690</idno>
                  <idno type="IDREF">https://www.idref.fr/134571533</idno>
                  <affiliation ref="#struct-171463"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Cécile</forename>
                    <surname>Herrmann-Storck</surname>
                  </persName>
                  <idno type="halauthorid">1168452-0</idno>
                  <affiliation ref="#struct-328176"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Philippe</forename>
                    <surname>Kadhel</surname>
                  </persName>
                  <idno type="halauthorid">480117-0</idno>
                  <affiliation ref="#struct-328176"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Cédric</forename>
                    <surname>Laouénan</surname>
                  </persName>
                  <idno type="idhal" notation="numeric">771320</idno>
                  <idno type="halauthorid" notation="string">709802-771320</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-3681-6314</idno>
                  <idno type="IDREF">https://www.idref.fr/138946159</idno>
                  <affiliation ref="#struct-247341"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Yoann</forename>
                    <surname>Madec</surname>
                  </persName>
                  <email type="md5">1b0e28c03e06f2b3d100970d7c714029</email>
                  <email type="domain">pasteur.fr</email>
                  <idno type="idhal" notation="string">yoann-madec</idno>
                  <idno type="idhal" notation="numeric">734914</idno>
                  <idno type="halauthorid" notation="string">2524226-734914</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-6201-1261</idno>
                  <affiliation ref="#struct-31480"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Alice</forename>
                    <surname>Monthieux</surname>
                  </persName>
                  <idno type="halauthorid">990126-0</idno>
                  <affiliation ref="#struct-420321"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Mathieu</forename>
                    <surname>Nacher</surname>
                  </persName>
                  <email type="md5">448f23025d0c0875fe64008bd4d6e303</email>
                  <email type="domain">gmail.com</email>
                  <idno type="idhal" notation="string">mathieu-nacher</idno>
                  <idno type="idhal" notation="numeric">11286</idno>
                  <idno type="halauthorid" notation="string">19684-11286</idno>
                  <idno type="ORCID">https://orcid.org/0000-0001-9397-3204</idno>
                  <idno type="IDREF">https://www.idref.fr/087955512</idno>
                  <affiliation ref="#struct-171463"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Fatiha</forename>
                    <surname>Najioullah</surname>
                  </persName>
                  <email type="md5">23314559be47ccb30ea359de0dd52940</email>
                  <email type="domain">chu-martinique.fr</email>
                  <idno type="idhal" notation="numeric">1290430</idno>
                  <idno type="halauthorid" notation="string">471565-1290430</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-2922-1400</idno>
                  <affiliation ref="#struct-494317"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Dominique</forename>
                    <surname>Rousset</surname>
                  </persName>
                  <email type="md5">43b50d741efa4204f090a1aeb7b63e08</email>
                  <email type="domain">pasteur.fr</email>
                  <idno type="idhal" notation="string">dominique-rousset211</idno>
                  <idno type="idhal" notation="numeric">185062</idno>
                  <idno type="halauthorid" notation="string">43761-185062</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-1473-3147</idno>
                  <idno type="IDREF">https://www.idref.fr/224013033</idno>
                  <affiliation ref="#struct-300193"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Catherine</forename>
                    <surname>Ryan</surname>
                  </persName>
                  <idno type="halauthorid">1021551-0</idno>
                  <affiliation ref="#struct-328176"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Kinda</forename>
                    <surname>Schepers</surname>
                  </persName>
                  <idno type="halauthorid">1064673-0</idno>
                  <affiliation ref="#struct-503020"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Sofia</forename>
                    <surname>Stegmann-Planchard</surname>
                  </persName>
                  <idno type="halauthorid">1334394-0</idno>
                  <affiliation ref="#struct-1196168"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Benoît</forename>
                    <surname>Tressières</surname>
                  </persName>
                  <idno type="halauthorid">719283-0</idno>
                  <affiliation ref="#struct-171463"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Jean-Luc</forename>
                    <surname>Voluménie</surname>
                  </persName>
                  <idno type="halauthorid">1334395-0</idno>
                  <affiliation ref="#struct-363873"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Samson</forename>
                    <surname>Yassinguezo</surname>
                  </persName>
                  <idno type="halauthorid">1334396-0</idno>
                  <affiliation ref="#struct-494314"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Eustase</forename>
                    <surname>Janky</surname>
                  </persName>
                  <idno type="halauthorid">480118-0</idno>
                  <affiliation ref="#struct-328176"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Arnaud</forename>
                    <surname>Fontanet</surname>
                  </persName>
                  <email type="md5">c75d171698d20a4c4f2f1c57dac264a5</email>
                  <email type="domain">pasteur.fr</email>
                  <idno type="idhal" notation="numeric">1584871</idno>
                  <idno type="halauthorid" notation="string">158599-1584871</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-5239-6110</idno>
                  <affiliation ref="#struct-31480"/>
                  <affiliation ref="#struct-484404"/>
                  <affiliation ref="#struct-300351"/>
                </author>
              </analytic>
              <monogr>
                <idno type="halJournalId" status="VALID">7381</idno>
                <idno type="issn">0028-4793</idno>
                <idno type="eissn">1533-4406</idno>
                <title level="j">New England Journal of Medicine</title>
                <imprint>
                  <publisher>Massachusetts Medical Society</publisher>
                  <biblScope unit="volume">378</biblScope>
                  <biblScope unit="issue">11</biblScope>
                  <biblScope unit="pp">985-994</biblScope>
                  <date type="datePub">2018-03-15</date>
                </imprint>
              </monogr>
              <idno type="doi">10.1056/NEJMoa1709481</idno>
              <idno type="pubmed">29539287</idno>
            </biblStruct>
          </sourceDesc>
          <profileDesc>
            <langUsage>
              <language ident="en">English</language>
            </langUsage>
            <textClass>
              <classCode scheme="mesh">Adolescent</classCode>
              <classCode scheme="mesh">Adult</classCode>
              <classCode scheme="mesh">Female</classCode>
              <classCode scheme="mesh">Fetal Diseases</classCode>
              <classCode scheme="mesh">Humans</classCode>
              <classCode scheme="mesh">French Guiana</classCode>
              <classCode scheme="mesh">Guadeloupe</classCode>
              <classCode scheme="mesh">Infant, Newborn</classCode>
              <classCode scheme="mesh">Martinique</classCode>
              <classCode scheme="mesh">Microcephaly</classCode>
              <classCode scheme="mesh">Middle Aged</classCode>
              <classCode scheme="mesh">Pregnancy</classCode>
              <classCode scheme="mesh">Pregnancy Trimesters</classCode>
              <classCode scheme="mesh">Pregnancy Complications, Infectious</classCode>
              <classCode scheme="mesh">Pregnancy Outcome</classCode>
              <classCode scheme="mesh">Young Adult</classCode>
              <classCode scheme="mesh">Amniotic Fluid</classCode>
              <classCode scheme="mesh">Zika Virus</classCode>
              <classCode scheme="mesh">Zika Virus Infection</classCode>
              <classCode scheme="mesh">Chromosome Disorders</classCode>
              <classCode scheme="mesh">Cohort Studies</classCode>
              <classCode scheme="mesh">Congenital Abnormalities</classCode>
              <classCode scheme="halDomain" n="sdv">Life Sciences [q-bio]</classCode>
              <classCode scheme="halTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halOldTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halTreeTypology" n="ART">Journal articles</classCode>
            </textClass>
            <abstract xml:lang="en">
              <p>BACKGROUND:The risk of congenital neurologic defects related to Zika virus (ZIKV) infection has ranged from 6 to 42% in various reports. The aim of this study was to estimate this risk among pregnant women with symptomatic ZIKV infection in French territories in the Americas.METHODS:From March 2016 through November 2016, we enrolled in this prospective cohort study pregnant women with symptomatic ZIKV infection that was confirmed by polymerase-chain-reaction (PCR) assay. The analysis included all data collected up to April 27, 2017, the date of the last delivery in the cohort.RESULTS:Among the 555 fetuses and infants in the 546 pregnancies included in the analysis, 28 (5.0%) were not carried to term or were stillborn, and 527 were born alive. Neurologic and ocular defects possibly associated with ZIKV infection were seen in 39 fetuses and infants (7.0%; 95% confidence interval, 5.0 to 9.5); of these, 10 were not carried to term because of termination of pregnancy for medical reasons, 1 was stillborn, and 28 were live-born. Microcephaly (defined as head circumference more than 2 SD below the mean for sex and gestational age) was detected in 32 fetuses and infants (5.8%), of whom 9 (1.6%) had severe microcephaly (more than 3 SD below the mean). Neurologic and ocular defects were more common when ZIKV infection occurred during the first trimester (24 of 189 fetuses and infants [12.7%]) than when it occurred during the second trimester (9 of 252 [3.6%]) or third trimester (6 of 114 [5.3%]) (P=0.001).CONCLUSIONS:Among pregnant women with symptomatic, PCR-confirmed ZIKV infection, birth defects possibly associated with ZIKV infection were present in 7% of fetuses and infants. Defects occurred more frequently in fetuses and infants whose mothers had been infected early in pregnancy. Longer-term follow-up of infants is required to assess any manifestations not detected at birth. (Funded by the French Ministry of Health and others; ClinicalTrials.gov number, NCT02916732 .).</p>
            </abstract>
            <particDesc>
              <org type="consortium">We thank the women who participated in this study; all the physicians, midwives, clinical research assistants, health officers, and epidemiologists who helped conduct this study in each of the French territories in the Americas: Myriam Atine, Lyderic Aubert, Marie Barrau, Kebe Beavogui, Christelle Celeste, Joelle Colat-Peyron, Elvire Couchy, Véronique Davidas, Lucetta Delver, Jacqueline Dubois, Stanie Gaete, Dorothée Harrois, Marie-Laure Lalanne-Mistrih, Mathilde Melin, Marie-France Mirane, Francelise Nadessein, Marie-Josée Pelczar, Véronique Plantier, Céline Rocquet, Magdalena Saint-Marc, Patrick Saint-Martin, Valérie Soter, Ingrid Soubdhan, Jennifer Taillefond, Lambo Velonasy, and Véronique Walter (Guadeloupe); Nicole Ambroisine, Gilda Belrose, Alain Blateau, Patricia Blondel, Isabelle Calmont, Valérie Decatrelle, Michèle Gueneret, Eugénie Jolivet, Isabelle Komla-Soukha, Corinne Plavonil, Marie-andrée Pyram, and Jean-Luc Voluménie (Martinique); Antoine Adenis, Audrey Andrieu, Luisiane Carvalho, Sandy Dabrowski, Céline Delorme, Maryvonne Dueymes, Aniza Fahrasmane, Arthur Felix, Hélène Hilderal, Anne Jolivet, Justine Krajewsky, Véronique Lambert, Thomas Lemaitre, Myriam Livain, Jérémie Pasquier, Marion Petit-Sinturel, Céline Pomar, Léo Pomar, and Stéphanie Rogier (French Guiana); and David Baud (University of Lausanne, Switzerland) and Rebecca Grant (Institut Pasteur de Paris, France) for their critical review of an earlier version of the manuscript.</org>
            </particDesc>
          </profileDesc>
        </biblFull>
      </listBibl>
    </body>
    <back>
      <listOrg type="structures">
        <org type="institution" xml:id="struct-328176" status="VALID">
          <idno type="ROR">https://ror.org/04sfmcd28</idno>
          <orgName>CHU Pointe-à-Pitre / Abymes [Guadeloupe]</orgName>
          <desc>
            <address>
              <addrLine>Route de Chauvel - BP 465 - 97159 Pointe-à-Pitre cedex</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.chu-guadeloupe.fr</ref>
          </desc>
        </org>
        <org type="laboratory" xml:id="struct-171463" status="VALID">
          <orgName>Centre d'investigation clinique Antilles-Guyane</orgName>
          <orgName type="acronym">CIC - Antilles Guyane</orgName>
          <desc>
            <address>
              <addrLine>Cayenne</addrLine>
              <country key="GF"/>
            </address>
          </desc>
          <listRelation>
            <relation name="CIE802" active="#struct-303623" type="direct"/>
            <relation active="#struct-328176" type="direct"/>
            <relation active="#struct-494314" type="direct"/>
            <relation active="#struct-494317" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-93016" status="OLD">
          <idno type="IdRef">026603136</idno>
          <idno type="ROR">https://ror.org/02ryfmr77</idno>
          <orgName>Université des Antilles et de la Guyane</orgName>
          <orgName type="acronym">UAG</orgName>
          <date type="start">1982-07-02</date>
          <date type="end">2015-06-24</date>
          <desc>
            <address>
              <addrLine>Fouillole - BP 250 - 97157 Pointe-à-Pitre</addrLine>
              <country key="GP"/>
            </address>
            <ref type="url">http://www.univ-ag.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-363873" status="VALID">
          <orgName>Maison de la Femme de la Mère et de l'Enfant [CHU de la Martinique]</orgName>
          <orgName type="acronym">MFME [Fort de France]</orgName>
          <desc>
            <address>
              <addrLine>CS 90632 – 97261 Fort de France Cedex</addrLine>
              <country key="MQ"/>
            </address>
          </desc>
          <listRelation>
            <relation active="#struct-494317" type="direct"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-31480" status="OLD">
          <idno type="RNSR">200118132J</idno>
          <orgName>Epidémiologie des Maladies Emergentes - Emerging Diseases Epidemiology</orgName>
          <date type="end">2021-07-21</date>
          <desc>
            <address>
              <addrLine>Département Infection et Epidémiologie, 25-28 rue du Docteur Roux, F-75724 Paris Cedex 15</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://research.pasteur.fr/en/team/epidemiology-of-emerging-diseases/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-300027" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-461591" status="VALID">
          <idno type="ROR">https://ror.org/00dfw9p58</idno>
          <idno type="Wikidata">Q24933114</idno>
          <orgName>Santé publique France - French National Public Health Agency [Saint-Maurice, France]</orgName>
          <date type="start">2016-05-01</date>
          <desc>
            <address>
              <addrLine>Santé publique France (siège social) 12, rue du Val d'Osne 94415 Saint-Maurice cedex</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.santepubliquefrance.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-487342" status="VALID">
          <orgName>Centre Hospitalier de l'Ouest Guyanais Franck Joly [Saint-Laurent-du-Maroni, Guyane Française]</orgName>
          <orgName type="acronym">CHOG</orgName>
          <desc>
            <address>
              <addrLine>16 avenue du Général de Gaulle, 97393 Saint-Laurent-du-Maroni.</addrLine>
              <country key="GF"/>
            </address>
            <ref type="url">https://chog.fr/</ref>
          </desc>
        </org>
        <org type="regroupinstitution" xml:id="struct-494317" status="VALID">
          <orgName>Centre Hospitalier Universitaire de Martinique [Fort-de-France, Martinique]</orgName>
          <orgName type="acronym">CHU de Martinique</orgName>
          <date type="start">2013-01-01</date>
          <desc>
            <address>
              <addrLine>97261 Fort-de-France Cedex</addrLine>
              <country key="MQ"/>
            </address>
            <ref type="url">https://www.chu-martinique.fr/</ref>
          </desc>
        </org>
        <org type="laboratory" xml:id="struct-247341" status="OLD">
          <idno type="IdRef">235514829</idno>
          <idno type="RNSR">201420743R</idno>
          <orgName>Infection, Anti-microbiens, Modélisation, Evolution</orgName>
          <orgName type="acronym">IAME (UMR_S_1137 / U1137)</orgName>
          <date type="end">2019-12-31</date>
          <desc>
            <address>
              <addrLine>Faculté de médecine Paris Diderot Paris 7 - site Bichat - 16 rue Henri Huchard 75890 Paris Cedex 18</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.iame-research.center/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-15786" type="direct"/>
            <relation name="UMR_S_1137" active="#struct-300301" type="direct"/>
            <relation active="#struct-303171" type="direct"/>
            <relation name="U1137" active="#struct-303623" type="direct"/>
          </listRelation>
        </org>
        <org type="regrouplaboratory" xml:id="struct-420321" status="OLD">
          <orgName>Université des Antilles et de la Guyane - UFR des sciences médicales</orgName>
          <orgName type="acronym">UAG UFR SM</orgName>
          <date type="end">2015-06-29</date>
          <desc>
            <address>
              <addrLine>Faculté de Médecine Hyacinthe Bastaraud - Campus de Fouillole - BP 145 - 97154 Pointe à Pitre Cedex</addrLine>
              <country key="GP"/>
            </address>
            <ref type="url">http://www.univ-ag.fr/fr/institution/u_f_r/ufr_medecine.html</ref>
          </desc>
          <listRelation>
            <relation active="#struct-93016" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-300193" status="VALID">
          <idno type="RNSR">194022845X</idno>
          <idno type="ROR">https://ror.org/01fp8z436</idno>
          <orgName>Institut Pasteur de la Guyane</orgName>
          <date type="start">1940-01-01</date>
          <desc>
            <address>
              <addrLine>23 Avenue Pasteur BP 6010 - 97306 Cayenne Cedex</addrLine>
              <country key="GF"/>
            </address>
            <ref type="url">http://www.pasteur-cayenne.fr/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-301247" type="direct"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-503020" status="OLD">
          <idno type="RNSR">201822855U</idno>
          <orgName>Maladies infectieuses et tropicales dans la Caraïbe</orgName>
          <orgName type="acronym">MAITC EA 4537</orgName>
          <date type="end">2021-12-31</date>
          <desc>
            <address>
              <addrLine>Laboratoire de Virologie-Immunologie, CHU de Fort-de-France, BP632, 97261 Fort-de-France cedex</addrLine>
              <country key="FR"/>
            </address>
          </desc>
          <listRelation>
            <relation active="#struct-328176" type="direct"/>
            <relation active="#struct-494317" type="direct"/>
            <relation name="EA 4537" active="#struct-524399" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-1196168" status="VALID">
          <orgName>Centre Hospitalier Louis Constant Fleming [Saint-Martin]</orgName>
          <orgName type="acronym">CH Saint-Martin</orgName>
          <desc>
            <address>
              <addrLine>BP 381 - Spring Concordia, 97150 SAINT MARTIN</addrLine>
              <country key="MF"/>
            </address>
            <ref type="url">https://www.chsaintmartin.org/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-494314" status="VALID">
          <orgName>Centre Hospitalier Andrée Rosemon [Cayenne, Guyane Française]</orgName>
          <desc>
            <address>
              <addrLine>Av des flamboyants, Cayenne 97306</addrLine>
              <country key="GF"/>
            </address>
            <ref type="url">http://www.ch-cayenne.fr/</ref>
          </desc>
        </org>
        <org type="laboratory" xml:id="struct-484404" status="OLD">
          <idno type="RNSR">201422233K</idno>
          <orgName>Center for Global Health Research and Education - Centre pour la Recherche et la Formation en Santé Mondiale</orgName>
          <orgName type="acronym">CGH</orgName>
          <date type="start">2014-09-01</date>
          <date type="end">2019-04-30</date>
          <desc>
            <address>
              <addrLine>25-28, rue du Docteur Roux, 75724 Paris Cedex 15</addrLine>
              <country key="FR"/>
            </address>
          </desc>
          <listRelation>
            <relation active="#struct-300027" type="direct"/>
            <relation active="#struct-301247" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-300351" status="VALID">
          <idno type="IdRef">027404978</idno>
          <idno type="ISNI">0000000121690459</idno>
          <idno type="ROR">https://ror.org/0175hh227</idno>
          <orgName>Conservatoire National des Arts et Métiers [Cnam]</orgName>
          <orgName type="acronym">Cnam</orgName>
          <desc>
            <address>
              <addrLine>292 Rue Saint-Martin, 75003 Paris</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.cnam.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-303623" status="VALID">
          <idno type="IdRef">026388278</idno>
          <idno type="ROR">https://ror.org/02vjkv261</idno>
          <orgName>Institut National de la Santé et de la Recherche Médicale</orgName>
          <orgName type="acronym">INSERM</orgName>
          <desc>
            <address>
              <addrLine>101, rue de Tolbiac, 75013 Paris</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.inserm.fr</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-300027" status="VALID">
          <idno type="IdRef">027936643</idno>
          <idno type="ISNI">0000 0001 2353 6535</idno>
          <idno type="ROR">https://ror.org/0495fxg12</idno>
          <orgName>Institut Pasteur [Paris]</orgName>
          <orgName type="acronym">IP</orgName>
          <date type="start">1887-06-04</date>
          <desc>
            <address>
              <addrLine>25-28, rue du docteur Roux, 75724 Paris cedex 15</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.pasteur.fr</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-15786" status="VALID">
          <idno type="ROR">https://ror.org/05f82e368</idno>
          <orgName>Université Paris 13</orgName>
          <orgName type="acronym">UP13</orgName>
          <desc>
            <address>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.univ-paris13.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-300301" status="OLD">
          <idno type="IdRef">027542084</idno>
          <idno type="ISNI">0000000121514068</idno>
          <idno type="ROR">https://ror.org/02n7qrg46</idno>
          <orgName>Université Paris Diderot - Paris 7</orgName>
          <orgName type="acronym">UPD7</orgName>
          <date type="end">2019-12-31</date>
          <desc>
            <address>
              <addrLine>5 rue Thomas-Mann - 75205 Paris cedex 13</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.univ-paris-diderot.fr</ref>
          </desc>
        </org>
        <org type="regroupinstitution" xml:id="struct-303171" status="VALID">
          <idno type="IdRef">19077990X</idno>
          <idno type="ROR">https://ror.org/001z21q04</idno>
          <orgName>Université Sorbonne Paris Cité</orgName>
          <orgName type="acronym">USPC</orgName>
          <date type="start">2010-01-01</date>
          <desc>
            <address>
              <addrLine>Université Sorbonne Paris Cité | 100-104, avenue de France | 75013 Paris</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.sorbonne-paris-cite.fr/fr</ref>
          </desc>
        </org>
        <org type="regroupinstitution" xml:id="struct-301247" status="VALID">
          <orgName>Pasteur Network (Réseau International des Instituts Pasteur)</orgName>
          <desc>
            <address>
              <addrLine>25, rue du Dr Roux 75724 Paris Cedex 15</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://pasteur-network.org/</ref>
          </desc>
        </org>
        <org type="regroupinstitution" xml:id="struct-524399" status="VALID">
          <idno type="IdRef">187841578</idno>
          <idno type="ROR">https://ror.org/02ryfmr77</idno>
          <orgName>Université des Antilles</orgName>
          <orgName type="acronym">UA</orgName>
          <date type="start">2015-01-01</date>
          <desc>
            <address>
              <addrLine>Université des Antilles | Fouillole - BP 250 - 97157 Pointe-à-Pitre</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.univ-antilles.fr/</ref>
          </desc>
        </org>
      </listOrg>
      <listOrg type="projects">
        <org type="anrProject" xml:id="projanr-24021" status="VALID">
          <idno type="anr">ANR-10-LABX-0062</idno>
          <orgName>IBEID</orgName>
          <desc>Integrative Biology of Emerging Infectious Diseases</desc>
          <date type="start">2010</date>
        </org>
      </listOrg>
    </back>
  </text>
</TEI>