%0 Journal Article %T Fatty acid profile in peri-prostatic adipose tissue and prostate cancer aggressiveness in African-Caribbean and Caucasian patients %+ Nutrition, croissance et cancer (U 1069) (N2C) %+ Clinical Investigation Center - INSERM 1415 %+ Institut de recherche en santé, environnement et travail (Irset) %+ Service Urologie, Hôpital Bretonneau %+ CHU Pontchaillou [Rennes] %+ Service d'urologie %+ Service d'urologie %+ Service de Chirurgie Urologique (BREST - Urologie) %+ CHRU Brest - Laboratoire d'Anatomo-Pathologie (CHU - AnaPath) %+ Service d'urologie %+ Service d'Anatomie Pathologique %A Figiel, Sandy %A Pinault, Michelle %A Domingo, Isabelle %A Guimaraes, Cyrille %A Guibon, Roseline %A Besson, Pierre %A Tavernier, Elsa %A Blanchet, Pascal %A Multigner, Luc %A Bruyère, Franck %A Haillot, Olivier %A Mathieu, Romain %A Vincendeau, Sebastien %A Rioux-Leclercq, Nathalie %A Lebdai, Souhil %A Azzouzi, Abdel-Rahmene %A Perrouin-Verbe, Marie-Aimee %A Fournier, Georges %A Doucet, Laurent %A Rigaud, Jerome %A Renaudin, Karine %A Mahéo, Karine %A Fromont, Gaëlle %Z Canceropole Grand Ouest: Region Centre, Region Pays de Loire, Region Bretagne, Region Poitou-Charentes %< avec comité de lecture %@ 0959-8049 %J European Journal of Cancer %I Elsevier %V 91 %P 107-115 %8 2018-03 %D 2018 %R 10.1016/j.ejca.2017.12.017 %M 29413967 %K Fatty acids %K Peri-prostatic adipose tissue %K Cancer aggressiveness %K Prostate cancer %K Linoleic acid %Z Life Sciences [q-bio]/Ecology, environment/HealthJournal articles %X Background - Genetic and nutritional factors have been linked to the risk of aggressive prostate cancer (PCa). The fatty acid (FA) composition of peri-prostatic adipose tissue (PPAT), which reflects the past FA intake, is potentially involved in PCa progression. We analysed the FA composition of PPAT, in correlation with the ethno-geographical origin of the patients and markers of tumour aggressiveness. Methods - From a cohort of 1000 men treated for PCa by radical prostatectomy, FA composition of PPAT was analysed in 156 patients (106 Caucasians and 50 African-Caribbeans), 78 with an indolent tumour (ISUP group 1 + pT2 + PSA <10 ng/mL) and 78 with an aggressive tumour (ISUP group 4-5 + pT3). The effect of FA extracted from PPAT on in-vitro migration of PCa cells DU145 was studied in 72 patients, 36 Caucasians, and 36 African-Caribbeans. Results - FA composition differed according to the ethno-geographical origin. Linoleic acid, an essential n-6 FA, was 2-fold higher in African-Caribbeans compared with Caucasian patients, regardless of disease aggressiveness. In African-Caribbeans, the FA profile associated with PCa aggressiveness was characterised by low level of linoleic acid along with high levels of saturates. In Caucasians, a weak and negative association was observed between eicosapentaenoic acid level (an n-3 FA) and disease aggressiveness. In-vitro migration of PCa cells using PPAT from African-Caribbean patients was associated with lower content of linoleic acid. Conclusion - These results highlight an important ethno-geographical variation of PPAT, in both their FA content and association with tumour aggressiveness. %G English %L hal-01730279 %U https://univ-rennes.hal.science/hal-01730279 %~ UNIV-RENNES1 %~ UNIV-TOURS %~ UNIV-ANGERS %~ IFR140 %~ GIP-BE %~ UNAM %~ HL %~ IRSET %~ STATS-UR1 %~ IRSET-SMS %~ IRSET-CCII %~ IRSET-TREC %~ IRSET-HIAEC %~ IRSET-SMLF %~ IRSET-ERD %~ IRSET-VCER %~ IRSET-NEED %~ IRSET-TNGC %~ UR1-UFR-SVE %~ UR1-HAL %~ UR1-SDV %~ IRSET-8 %~ IRSET-9 %~ TEST-UR-CSS %~ UNIV-RENNES %~ UR1-BIO-SA %~ TEST3-HALCNRS %~ N2C