<?xml version="1.0" encoding="utf-8"?>
<TEI xmlns="http://www.tei-c.org/ns/1.0" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:hal="http://hal.archives-ouvertes.fr/" xmlns:gml="http://www.opengis.net/gml/3.3/" xmlns:gmlce="http://www.opengis.net/gml/3.3/ce" version="1.1" xsi:schemaLocation="http://www.tei-c.org/ns/1.0 http://api.archives-ouvertes.fr/documents/aofr-sword.xsd">
  <teiHeader>
    <fileDesc>
      <titleStmt>
        <title>HAL TEI export of hal-01671761</title>
      </titleStmt>
      <publicationStmt>
        <distributor>CCSD</distributor>
        <availability status="restricted">
          <licence target="https://creativecommons.org/publicdomain/zero/1.0/">CC0 1.0 - Universal</licence>
        </availability>
        <date when="2026-05-19T21:34:07+02:00"/>
      </publicationStmt>
      <sourceDesc>
        <p part="N">HAL API Platform</p>
      </sourceDesc>
    </fileDesc>
  </teiHeader>
  <text>
    <body>
      <listBibl>
        <biblFull>
          <titleStmt>
            <title xml:lang="en">CD90 Expression Controls Migration and Predicts Dasatinib Response in Glioblastoma</title>
            <author role="crp">
              <persName>
                <forename type="first">Tony</forename>
                <surname>Avril</surname>
              </persName>
              <email type="md5">f717bca9fefb348c7ab9ab15dc8279c6</email>
              <email type="domain">rennes.unicancer.fr</email>
              <idno type="idhal" notation="numeric">1025422</idno>
              <idno type="halauthorid" notation="string">385970-1025422</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-1129-8514</idno>
              <affiliation ref="#struct-480830"/>
              <affiliation ref="#struct-301510"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Amandine</forename>
                <surname>Etcheverry</surname>
              </persName>
              <email type="md5">e1497c8e57a972b6d1c2a93cafb691d3</email>
              <email type="domain">univ-rennes1.fr</email>
              <idno type="idhal" notation="string">amandine-etcheverry</idno>
              <idno type="idhal" notation="numeric">13855</idno>
              <idno type="halauthorid" notation="string">8005-13855</idno>
              <idno type="ORCID">https://orcid.org/0000-0003-4092-8308</idno>
              <idno type="IDREF">https://www.idref.fr/165637269</idno>
              <affiliation ref="#struct-187162"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Raphael</forename>
                <surname>Pineau</surname>
              </persName>
              <idno type="halauthorid">788442-0</idno>
              <affiliation ref="#struct-480830"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Joanna</forename>
                <surname>Obacz</surname>
              </persName>
              <idno type="halauthorid">1157622-0</idno>
              <affiliation ref="#struct-480830"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Gwenaele</forename>
                <surname>Jegou</surname>
              </persName>
              <idno type="halauthorid">1289661-0</idno>
              <affiliation ref="#struct-480830"/>
              <affiliation ref="#struct-301510"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Florence</forename>
                <surname>Jouan</surname>
              </persName>
              <idno type="halauthorid">345667-0</idno>
              <affiliation ref="#struct-480830"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Pierre-Jean</forename>
                <surname>Le Reste</surname>
              </persName>
              <idno type="halauthorid">745157-0</idno>
              <affiliation ref="#struct-480830"/>
              <affiliation ref="#struct-301327"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Masumeh</forename>
                <surname>Hatami</surname>
              </persName>
              <idno type="halauthorid">1289662-0</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Rivka R.</forename>
                <surname>Colen</surname>
              </persName>
              <idno type="halauthorid">1097984-0</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Brett L.</forename>
                <surname>Carlson</surname>
              </persName>
              <idno type="halauthorid">1289663-0</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Paul A.</forename>
                <surname>Decker</surname>
              </persName>
              <idno type="halauthorid">1235892-0</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Jann N.</forename>
                <surname>Sarkaria</surname>
              </persName>
              <idno type="halauthorid">1289664-0</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Elodie</forename>
                <surname>Vauleon</surname>
              </persName>
              <email type="md5">b51e4baa493d749dfc7913869d5a0d87</email>
              <email type="domain">rennes.fnclcc.fr</email>
              <idno type="idhal" notation="numeric">765514</idno>
              <idno type="halauthorid" notation="string">610657-765514</idno>
              <idno type="IDREF">https://www.idref.fr/113696876</idno>
              <idno type="ORCID">https://orcid.org/0000-0001-9019-9778</idno>
              <idno type="GOOGLE SCHOLAR">https://scholar.google.fr/citations?user=hJKlEz8AAAAJ</idno>
              <idno type="VIAF">https://viaf.org/viaf/213214157</idno>
              <idno type="ISNI">http://isni.org/isni/000000035879124X</idno>
              <affiliation ref="#struct-480830"/>
              <affiliation ref="#struct-301510"/>
              <affiliation ref="#struct-187162"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Dan Cristian</forename>
                <surname>Chiforeanu</surname>
              </persName>
              <idno type="halauthorid">591525-0</idno>
              <affiliation ref="#struct-301327"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Anne</forename>
                <surname>Clavreul</surname>
              </persName>
              <email type="md5">f9b9bf945acc48fc42f20dd7f303e42d</email>
              <email type="domain">univ-angers.fr</email>
              <idno type="idhal" notation="string">anne-clavreul</idno>
              <idno type="idhal" notation="numeric">749080</idno>
              <idno type="halauthorid" notation="string">25664-749080</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-4477-8282</idno>
              <affiliation ref="#struct-151939"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Jean</forename>
                <surname>Mosser</surname>
              </persName>
              <idno type="halauthorid">154161-0</idno>
              <affiliation ref="#struct-187162"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Eric</forename>
                <surname>Chevet</surname>
              </persName>
              <idno type="idhal" notation="numeric">762834</idno>
              <idno type="halauthorid" notation="string">473707-762834</idno>
              <idno type="ORCID">https://orcid.org/0000-0001-5855-4522</idno>
              <idno type="IDREF">https://www.idref.fr/132451565</idno>
              <idno type="IDREF">https://www.idref.fr/200269747</idno>
              <affiliation ref="#struct-480830"/>
              <affiliation ref="#struct-301510"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Veronique</forename>
                <surname>Quillien</surname>
              </persName>
              <idno type="halauthorid">518569-0</idno>
              <affiliation ref="#struct-480830"/>
              <affiliation ref="#struct-301510"/>
              <affiliation ref="#struct-187162"/>
            </author>
            <editor role="depositor">
              <persName>
                <forename>Laurent</forename>
                <surname>Jonchère</surname>
              </persName>
              <email type="md5">dc1f1e9bdb3dc2065f8bf1bfd5663118</email>
              <email type="domain">univ-rennes.fr</email>
            </editor>
            <funder>la Ligue Contre le Cancer Comite d'Ille-et-Villaine, d'Indre-et-Loire et du Morbihan</funder>
            <funder>Region Bretagne AAP CRITT sante</funder>
            <funder>Aidez la recherche! from the Centre Eugene Marquis</funder>
            <funder>la Ligue Contre le Cancer Comite des Landes (LARGE project), l'Institut National du Cancer [INCa_5869, INCa_7981, PLBIO: 2015-111]</funder>
            <funder>EU H2020 MSCA (TRAINERS) [ITN-675448]</funder>
          </titleStmt>
          <editionStmt>
            <edition n="v1" type="current">
              <date type="whenSubmitted">2018-03-15 11:19:02</date>
              <date type="whenModified">2025-10-03 03:05:21</date>
              <date type="whenReleased">2018-03-15 11:44:54</date>
              <date type="whenProduced">2017-09-22</date>
              <date type="whenEndEmbargoed">2018-03-15</date>
              <ref type="file" target="https://univ-rennes.hal.science/hal-01671761v1/document">
                <date notBefore="2018-03-15"/>
              </ref>
              <ref type="file" subtype="author" n="1" target="https://univ-rennes.hal.science/hal-01671761v1/file/Avril%20-%20CD90%20expression%20controls%20migration.pdf" id="file-1734921-1774947">
                <date notBefore="2018-03-15"/>
              </ref>
              <ref type="externalLink" target="https://clincancerres.aacrjournals.org/content/clincanres/23/23/7360.full.pdf"/>
            </edition>
            <respStmt>
              <resp>contributor</resp>
              <name key="113861">
                <persName>
                  <forename>Laurent</forename>
                  <surname>Jonchère</surname>
                </persName>
                <email type="md5">dc1f1e9bdb3dc2065f8bf1bfd5663118</email>
                <email type="domain">univ-rennes.fr</email>
              </name>
            </respStmt>
          </editionStmt>
          <publicationStmt>
            <distributor>CCSD</distributor>
            <idno type="halId">hal-01671761</idno>
            <idno type="halUri">https://univ-rennes.hal.science/hal-01671761</idno>
            <idno type="halBibtex">avril:hal-01671761</idno>
            <idno type="halRefHtml">&lt;i&gt;Clinical Cancer Research&lt;/i&gt;, 2017, 23 (23), pp.7360-7374. &lt;a target="_blank" href="https://dx.doi.org/10.1158/1078-0432.CCR-17-1549"&gt;&amp;#x27E8;10.1158/1078-0432.CCR-17-1549&amp;#x27E9;&lt;/a&gt;</idno>
            <idno type="halRef">Clinical Cancer Research, 2017, 23 (23), pp.7360-7374. &amp;#x27E8;10.1158/1078-0432.CCR-17-1549&amp;#x27E9;</idno>
            <availability status="restricted">
              <licence target="https://about.hal.science/hal-authorisation-v1/">HAL Authorization<ref corresp="#file-1734921-1774947"/></licence>
            </availability>
          </publicationStmt>
          <seriesStmt>
            <idno type="stamp" n="INSERM">INSERM - Institut national de la santé et de la recherche médicale</idno>
            <idno type="stamp" n="UNIV-RENNES1">Université de Rennes 1</idno>
            <idno type="stamp" n="CNRS">CNRS - Centre national de la recherche scientifique</idno>
            <idno type="stamp" n="IFR140">SFR Biosit - Biologie et Santé CNRS UMS 3480</idno>
            <idno type="stamp" n="FNCLCC" corresp="INSERM">UNICANCER</idno>
            <idno type="stamp" n="MARQUIS" corresp="FNCLCC">Centre Eugène Marquis</idno>
            <idno type="stamp" n="HL">Publications CHU Rennes</idno>
            <idno type="stamp" n="IGDR">Institut Génétique et Développement de Rennes</idno>
            <idno type="stamp" n="STATS-UR1">Statistiques-HAL-UR1</idno>
            <idno type="stamp" n="IGDR-GFI">OncoGénomique Translationnelle (TOnG)</idno>
            <idno type="stamp" n="OSS">Chemistry Oncogenesis Stress Signaling</idno>
            <idno type="stamp" n="UR1-UFR-SVE">UFR SVE Sciences de la vie et de l'environnement</idno>
            <idno type="stamp" n="UR1-HAL">Publications labos UR1 dans HAL-Rennes 1</idno>
            <idno type="stamp" n="UR1-SDV">UR1 - publications SDV</idno>
            <idno type="stamp" n="TEST-UNIV-RENNES">TEST Université de Rennes</idno>
            <idno type="stamp" n="TEST-UR-CSS">TEST Université de Rennes CSS</idno>
            <idno type="stamp" n="UNIV-RENNES">Université de Rennes</idno>
            <idno type="stamp" n="TEST-HALCNRS">Collection test HAL CNRS</idno>
            <idno type="stamp" n="UR1-BIO-SA">Pôle UnivRennes - Biologie-Santé</idno>
          </seriesStmt>
          <notesStmt>
            <note type="audience" n="2">International</note>
            <note type="popular" n="0">No</note>
            <note type="peer" n="1">Yes</note>
          </notesStmt>
          <sourceDesc>
            <biblStruct>
              <analytic>
                <title xml:lang="en">CD90 Expression Controls Migration and Predicts Dasatinib Response in Glioblastoma</title>
                <author role="crp">
                  <persName>
                    <forename type="first">Tony</forename>
                    <surname>Avril</surname>
                  </persName>
                  <email type="md5">f717bca9fefb348c7ab9ab15dc8279c6</email>
                  <email type="domain">rennes.unicancer.fr</email>
                  <idno type="idhal" notation="numeric">1025422</idno>
                  <idno type="halauthorid" notation="string">385970-1025422</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-1129-8514</idno>
                  <affiliation ref="#struct-480830"/>
                  <affiliation ref="#struct-301510"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Amandine</forename>
                    <surname>Etcheverry</surname>
                  </persName>
                  <email type="md5">e1497c8e57a972b6d1c2a93cafb691d3</email>
                  <email type="domain">univ-rennes1.fr</email>
                  <idno type="idhal" notation="string">amandine-etcheverry</idno>
                  <idno type="idhal" notation="numeric">13855</idno>
                  <idno type="halauthorid" notation="string">8005-13855</idno>
                  <idno type="ORCID">https://orcid.org/0000-0003-4092-8308</idno>
                  <idno type="IDREF">https://www.idref.fr/165637269</idno>
                  <affiliation ref="#struct-187162"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Raphael</forename>
                    <surname>Pineau</surname>
                  </persName>
                  <idno type="halauthorid">788442-0</idno>
                  <affiliation ref="#struct-480830"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Joanna</forename>
                    <surname>Obacz</surname>
                  </persName>
                  <idno type="halauthorid">1157622-0</idno>
                  <affiliation ref="#struct-480830"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Gwenaele</forename>
                    <surname>Jegou</surname>
                  </persName>
                  <idno type="halauthorid">1289661-0</idno>
                  <affiliation ref="#struct-480830"/>
                  <affiliation ref="#struct-301510"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Florence</forename>
                    <surname>Jouan</surname>
                  </persName>
                  <idno type="halauthorid">345667-0</idno>
                  <affiliation ref="#struct-480830"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Pierre-Jean</forename>
                    <surname>Le Reste</surname>
                  </persName>
                  <idno type="halauthorid">745157-0</idno>
                  <affiliation ref="#struct-480830"/>
                  <affiliation ref="#struct-301327"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Masumeh</forename>
                    <surname>Hatami</surname>
                  </persName>
                  <idno type="halauthorid">1289662-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Rivka R.</forename>
                    <surname>Colen</surname>
                  </persName>
                  <idno type="halauthorid">1097984-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Brett L.</forename>
                    <surname>Carlson</surname>
                  </persName>
                  <idno type="halauthorid">1289663-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Paul A.</forename>
                    <surname>Decker</surname>
                  </persName>
                  <idno type="halauthorid">1235892-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Jann N.</forename>
                    <surname>Sarkaria</surname>
                  </persName>
                  <idno type="halauthorid">1289664-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Elodie</forename>
                    <surname>Vauleon</surname>
                  </persName>
                  <email type="md5">b51e4baa493d749dfc7913869d5a0d87</email>
                  <email type="domain">rennes.fnclcc.fr</email>
                  <idno type="idhal" notation="numeric">765514</idno>
                  <idno type="halauthorid" notation="string">610657-765514</idno>
                  <idno type="IDREF">https://www.idref.fr/113696876</idno>
                  <idno type="ORCID">https://orcid.org/0000-0001-9019-9778</idno>
                  <idno type="GOOGLE SCHOLAR">https://scholar.google.fr/citations?user=hJKlEz8AAAAJ</idno>
                  <idno type="VIAF">https://viaf.org/viaf/213214157</idno>
                  <idno type="ISNI">http://isni.org/isni/000000035879124X</idno>
                  <affiliation ref="#struct-480830"/>
                  <affiliation ref="#struct-301510"/>
                  <affiliation ref="#struct-187162"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Dan Cristian</forename>
                    <surname>Chiforeanu</surname>
                  </persName>
                  <idno type="halauthorid">591525-0</idno>
                  <affiliation ref="#struct-301327"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Anne</forename>
                    <surname>Clavreul</surname>
                  </persName>
                  <email type="md5">f9b9bf945acc48fc42f20dd7f303e42d</email>
                  <email type="domain">univ-angers.fr</email>
                  <idno type="idhal" notation="string">anne-clavreul</idno>
                  <idno type="idhal" notation="numeric">749080</idno>
                  <idno type="halauthorid" notation="string">25664-749080</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-4477-8282</idno>
                  <affiliation ref="#struct-151939"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Jean</forename>
                    <surname>Mosser</surname>
                  </persName>
                  <idno type="halauthorid">154161-0</idno>
                  <affiliation ref="#struct-187162"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Eric</forename>
                    <surname>Chevet</surname>
                  </persName>
                  <idno type="idhal" notation="numeric">762834</idno>
                  <idno type="halauthorid" notation="string">473707-762834</idno>
                  <idno type="ORCID">https://orcid.org/0000-0001-5855-4522</idno>
                  <idno type="IDREF">https://www.idref.fr/132451565</idno>
                  <idno type="IDREF">https://www.idref.fr/200269747</idno>
                  <affiliation ref="#struct-480830"/>
                  <affiliation ref="#struct-301510"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Veronique</forename>
                    <surname>Quillien</surname>
                  </persName>
                  <idno type="halauthorid">518569-0</idno>
                  <affiliation ref="#struct-480830"/>
                  <affiliation ref="#struct-301510"/>
                  <affiliation ref="#struct-187162"/>
                </author>
              </analytic>
              <monogr>
                <idno type="halJournalId" status="VALID">11763</idno>
                <idno type="issn">1078-0432</idno>
                <idno type="eissn">1557-3265</idno>
                <title level="j">Clinical Cancer Research</title>
                <imprint>
                  <publisher>American Association for Cancer Research</publisher>
                  <biblScope unit="volume">23</biblScope>
                  <biblScope unit="issue">23</biblScope>
                  <biblScope unit="pp">7360-7374</biblScope>
                  <date type="datePub">2017-09-22</date>
                  <date type="dateEpub">2017-09-23</date>
                </imprint>
              </monogr>
              <idno type="doi">10.1158/1078-0432.CCR-17-1549</idno>
              <idno type="pubmed">28939749</idno>
            </biblStruct>
          </sourceDesc>
          <profileDesc>
            <langUsage>
              <language ident="en">English</language>
            </langUsage>
            <textClass>
              <classCode scheme="halDomain" n="sdv.can">Life Sciences [q-bio]/Cancer</classCode>
              <classCode scheme="halDomain" n="sdv.neu.nb">Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology</classCode>
              <classCode scheme="halDomain" n="sdv.sp.pharma">Life Sciences [q-bio]/Pharmaceutical sciences/Pharmacology</classCode>
              <classCode scheme="halTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halOldTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halTreeTypology" n="ART">Journal articles</classCode>
            </textClass>
            <abstract xml:lang="en">
              <p>Purpose: CD90 (Thy-1) is a glycophosphatidylinositol-anchored glycoprotein considered as a surrogate marker for a variety of stem cells, including glioblastoma (GBM) stem cells (GSC). However, the molecular and cellular functions of CD90 remain unclear.Experimental Design: The function of CD90 in GBM was addressed using cellular models from immortalized and primary GBMlines, in vivo orthotopic mouse models, and GBM specimens' transcriptome associated with MRI features from GBM patients. CD90 expression was silenced in U251 and GBM primary cells and complemented in CD90-negative U87 cells.Results: We showed that CD90 is not only expressed on GSCs but also on more differentiated GBM cancer cells. In GBM patients, CD90 expression was associated with an adhesion/migration gene signature and with invasive tumor features. Modulation of CD90 expression in GBM cells dramatically affected their adhesion and migration properties. Moreover, orthotopic xenografts revealed that CD90 expression induced invasive phenotypes in vivo. Indeed, CD90 expression led to enhanced SRC and FAK signaling in our GBM cellular models and GBM patients' specimens. Pharmacologic inhibition of these signaling nodes blunted adhesion and migration in CD90-positive cells. Remarkably, dasatinib blunted CD90-dependent GBM cell invasion in vivo and killed CD90(high) primary GSC lines.Conclusions: Our data demonstrate that CD90 is an actor of GBM invasiveness through SRC-dependent mechanisms and could be used as a predictive factor for dasatinib response in CD90high GBM patients. (C) 2017 AACR.</p>
            </abstract>
          </profileDesc>
        </biblFull>
      </listBibl>
    </body>
    <back>
      <listOrg type="structures">
        <org type="laboratory" xml:id="struct-480830" status="OLD">
          <idno type="IdRef">192863495</idno>
          <idno type="RNSR">201521288D</idno>
          <idno type="ROR">https://ror.org/00bf6bf92</idno>
          <orgName>Chemistry, Oncogenesis, Stress and Signaling</orgName>
          <orgName type="acronym">COSS</orgName>
          <date type="start">2017-01-01</date>
          <date type="end">2022-03-22</date>
          <desc>
            <address>
              <addrLine>Université de Rennes1 - CLCC Eugène Marquis, Rue de la Bataille Flandres Dunkerque, Bat D, 35042 Rennes</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://oss-clcc-rennes.com/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-105160" type="direct"/>
            <relation active="#struct-301510" type="direct"/>
            <relation active="#struct-502406" type="indirect"/>
            <relation name="U1242" active="#struct-303623" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-301510" status="VALID">
          <idno type="ROR">https://ror.org/01yezas83</idno>
          <orgName>CRLCC Eugène Marquis</orgName>
          <orgName type="acronym">CRLCC</orgName>
          <desc>
            <address>
              <addrLine>Avenue Bataille Flandres-Dunkerque 35042 RENNES CEDEX</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.centre-eugene-marquis.fr/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-502406" type="direct"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-187162" status="VALID">
          <idno type="IdRef">178579254</idno>
          <idno type="ISNI">000000040609882X</idno>
          <idno type="RNSR">201220436R</idno>
          <idno type="ROR">https://ror.org/036xhtv26</idno>
          <orgName>Institut de Génétique et Développement de Rennes</orgName>
          <orgName type="acronym">IGDR</orgName>
          <date type="start">2012-01-01</date>
          <desc>
            <address>
              <addrLine>Faculté de Médecine - CS 34317 2 Av du Professeur Léon Bernard 35043 Rennes Cedex</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://igdr.univ-rennes.fr/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-105160" type="direct"/>
            <relation name="UMR6290" active="#struct-441569" type="direct"/>
            <relation active="#struct-453207" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-301327" status="VALID">
          <idno type="ROR">https://ror.org/05qec5a53</idno>
          <orgName>Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou]</orgName>
          <desc>
            <address>
              <addrLine>2 Rue Henri le Guilloux, 35000 Rennes</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.chu-rennes.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-151939" status="VALID">
          <idno type="ISNI">0000 0004 0472 0283</idno>
          <idno type="ROR">https://ror.org/0250ngj72</idno>
          <orgName>Centre Hospitalier Universitaire d'Angers</orgName>
          <orgName type="acronym">CHU Angers</orgName>
          <desc>
            <address>
              <addrLine>4 rue Larrey - 49933 Angers cedex 9</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.chu-angers.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-105160" status="VALID">
          <idno type="IdRef">26693823X</idno>
          <idno type="ROR">https://ror.org/015m7wh34</idno>
          <orgName>Université de Rennes</orgName>
          <orgName type="acronym">UR</orgName>
          <desc>
            <address>
              <addrLine>Campus de Beaulieu, 263 avenue Général Leclerc, CS 74205, 35042 RENNES CEDEX</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.univ-rennes.fr/</ref>
          </desc>
        </org>
        <org type="regroupinstitution" xml:id="struct-502406" status="VALID">
          <orgName>UNICANCER</orgName>
          <desc>
            <address>
              <addrLine>101, rue de Tolbiac, 75654 Paris Cedex 13</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.unicancer.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-303623" status="VALID">
          <idno type="IdRef">026388278</idno>
          <idno type="ROR">https://ror.org/02vjkv261</idno>
          <orgName>Institut National de la Santé et de la Recherche Médicale</orgName>
          <orgName type="acronym">INSERM</orgName>
          <desc>
            <address>
              <addrLine>101, rue de Tolbiac, 75013 Paris</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.inserm.fr</ref>
          </desc>
        </org>
        <org type="regroupinstitution" xml:id="struct-441569" status="VALID">
          <idno type="IdRef">02636817X</idno>
          <idno type="ISNI">0000000122597504</idno>
          <idno type="ROR">https://ror.org/02feahw73</idno>
          <orgName>Centre National de la Recherche Scientifique</orgName>
          <orgName type="acronym">CNRS</orgName>
          <date type="start">1939-10-19</date>
          <desc>
            <address>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.cnrs.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-453207" status="VALID">
          <idno type="IdRef">200295462</idno>
          <idno type="RNSR">201220717W</idno>
          <idno type="ROR">https://ror.org/05cx7ek10</idno>
          <orgName>Structure Fédérative de Recherche en Biologie et Santé de Rennes</orgName>
          <orgName type="acronym">Biosit : Biologie - Santé - Innovation Technologique</orgName>
          <date type="start">2012-01-01</date>
          <desc>
            <address>
              <addrLine>Université de Rennes - Campus Santé Villejean -  2, avenue Professeur Léon Bernard 35043 Rennes cedex</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://biosit.univ-rennes.fr/</ref>
          </desc>
        </org>
      </listOrg>
    </back>
  </text>
</TEI>