%0 Conference Paper %F Oral %T Submillimetre spectroscopy of the volatile metabolome %+ Institut de Physique de Rennes (IPR) %A Bondu, François %< avec comité de lecture %B 9th terahertz days %C Dunkerque, France %8 2017-06-12 %D 2017 %Z Physics [physics]/Physics [physics]/Optics [physics.optics] %Z Physics [physics]/Physics [physics]/Instrumentation and Detectors [physics.ins-det] %Z Life Sciences [q-bio]/Microbiology and Parasitology/BacteriologyConference papers %X Gaseous ensembles of molecules, called the volatilome, are fingerprints [1]–[3] of the metabolism of living organisms, including bacteria and archeobacteria. The submillimetre spectroscopy of these mixtures [4] could provide an interesting analysis alternative to gas chromatography coupled to mass spectroscopy (GC-MS) as there would be less effects (heating, ionization) damaging the integrity of large molecules. The characterization of ensembles would then in medical situations [5], [6] discriminate pathological situations or possibly identify bacteria resistant to antibiotics, and in food industry [7], [8] survey fermentation processes. The realization of an instrument meets several challenges. (a) The optical generation of submillimetre waves promises to attain a large frequency span, thus a large molecule span: we will present results towards such a compact and tuneable source. (b) The detection system should present a large signal to noise ratio, in order to detect molecules at trace levels. (c) The sampling system should take care that a large fraction of volatile biological molecules are actually liquid at ambient temperature and pressure. %G English %2 https://univ-rennes.hal.science/hal-01622216/document %2 https://univ-rennes.hal.science/hal-01622216/file/9th-days-abstract_Bondu.pdf %L hal-01622216 %U https://univ-rennes.hal.science/hal-01622216 %~ UNIV-RENNES1 %~ CNRS %~ OSUR %~ IPR %~ IPR-OP %~ UR1-SPM %~ UR1-UFR-SPM %~ UR1-HAL %~ UR1-SDLM %~ TEST-UNIV-RENNES %~ TEST-UR-CSS %~ UNIV-RENNES %~ UR1-MMS