The interaction of iron and the genome: For better and for worse - Université de Rennes Access content directly
Journal Articles Mutation Research - Reviews Year : 2017

The interaction of iron and the genome: For better and for worse

Abstract

Iron, as an essential nutrient, and the DNA, as the carrier of genetic information which is physically compacted into chromosomes, are both needed for normal life and well-being. Therefore, it is not surprising that close interactions exist between iron and the genome. On the one hand, iron, especially when present in excess, may alter genome stability through oxidative stress, and may favor cell cycle abnormalities and the development of malignant diseases. The genome also receives a feedback signal from the systemic iron status, leading to promotion of expression of genes that regulate iron metabolism. Conversely, on the other hand, DNA mutations may cause genetic iron-related diseases such as hemochromatosis, archetype of iron-overload diseases, or refractory iron deficiency anemia (IRIDA). © 2017 Elsevier B.V.
Fichier principal
Vignette du fichier
Troadec et al. - 2017 - The interaction of iron and the genome for better.pdf (677.81 Ko) Télécharger le fichier
Origin : Files produced by the author(s)
Loading...

Dates and versions

hal-01616421 , version 1 (24-10-2017)

Identifiers

Cite

Marie-Bérengère Troadec, Olivier Loréal, P. Brissot. The interaction of iron and the genome: For better and for worse. Mutation Research - Reviews, 2017, 774, pp.25-32. ⟨10.1016/j.mrrev.2017.09.002⟩. ⟨hal-01616421⟩
266 View
469 Download

Altmetric

Share

Gmail Facebook Twitter LinkedIn More