%0 Journal Article %T Regulation of the unfolded protein response by noncoding RNA %+ Apoptosis Research Centre (ARC) %+ Chemistry, Oncogenesis, Stress and Signaling (COSS) %+ CRLCC Eugène Marquis (CRLCC) %A Mcmahon, Mari %A Samali, Afshin %A Chevet, Eric %Z 2010NovPR13, Breast Cancer Campaign %Z HRA-POR-2014-643, Health Research Board %Z 13/RC/2073, Science Foundation Ireland %Z INCa_5869, Institut National du Cancer %Z MSCA ITN-675448, EU H2020 %Z ARED-Région Bretagne %< avec comité de lecture %@ 0363-6143 %J American Journal of Physiology - Cell Physiology %I American Physiological Society %V 313 %N 3 %P C243-C254 %8 2017-09 %D 2017 %R 10.1152/ajpcell.00293.2016 %M 28637678 %K noncoding RNA %K endoplasmic %K proteostasis %K Stress %Z Life Sciences [q-bio]/Cancer %Z Life Sciences [q-bio]/Biochemistry, Molecular Biology %Z Life Sciences [q-bio]/Cellular Biology/Subcellular Processes [q-bio.SC]Journal articles %X Cells are exposed to various intrinsic and extrinsic stresses in both physiological and pathological conditions. To adapt to those conditions, cells have evolved various mechanisms to cope with the disturbances in protein demand, largely through the unfolded protein response (UPR) in the endoplasmic reticulum (ER), but also through the integrated stress response (ISR). Both responses initiate downstream signaling to transcription factors that, in turn, trigger adaptive programs and/or in the case of prolonged stress, cell death mechanisms. Recently, noncoding RNAs, including microRNA and long noncoding RNA, have emerged as key players in the stress responses. These noncoding RNAs act as both regulators and effectors of the UPR and fine-tune the output of the stress signaling pathways. Although much is known about the UPR and the cross talk that exists between pathways, the contribution of small noncoding RNA has not been fully assessed. Herein we bring together and review the current known functions of noncoding RNA in regulating adaptive pathways in both physiological and pathophysiological conditions, illustrating how they operate within the known UPR functions and contribute to diverse cellular outcomes. %G English %2 https://univ-rennes.hal.science/hal-01586174/document %2 https://univ-rennes.hal.science/hal-01586174/file/McMahon-Regulation%20of%20the%20Unfolded%20Protein-Accepted.pdf %L hal-01586174 %U https://univ-rennes.hal.science/hal-01586174 %~ INSERM %~ UNIV-RENNES1 %~ FNCLCC %~ MARQUIS %~ STATS-UR1 %~ OSS %~ UR1-UFR-SVE %~ UR1-HAL %~ UR1-SDV %~ TEST-UNIV-RENNES %~ TEST-UR-CSS %~ UNIV-RENNES %~ UR1-BIO-SA