%0 Journal Article %T Direct C3-Arylation of 2H-Indazole Derivatives with Aryl Bromides by using Low Loading of a Phosphine-free Palladium Catalyst %+ Institut des Sciences Chimiques de Rennes (ISCR) %+ Département de chimie %A Belkessam, Fatma %A Aidene, Mohand %A Soulé, Jean-François %A Doucet, Henri %Z CNRS %Z Rennes Metropole %< avec comité de lecture %@ 1867-3899 %J ChemCatChem %I Wiley %V 9 %N 12 %P 2239--2249 %8 2017-06-22 %D 2017 %R 10.1002/cctc.201601420 %K indazoles %K coupling reactions %K palladium %K c-h bond activation %K aryl bromides %Z Chemical Sciences/Organic chemistry %Z Chemical Sciences/CatalysisJournal articles %X The palladium-catalyzed direct arylation of 2 H-indazoles with aryl bromides for the preparation of 3-aryl-2 H-indazoles was found to proceed in high yields when using only 0.5–0.1 mol % Pd(OAc)2 catalyst and KOAc as inexpensive base. A wide variety of electron-deficient and electron-rich aryl bromides and also heteroaryl bromides has been successfully employed. Both electron-withdrawing and electron-donating substituents on the 2 H-indazoles are also tolerated. Moreover, the reaction can be performed in the “green” solvent cyclopentyl methyl ether. %G English %2 https://univ-rennes.hal.science/hal-01578529/document %2 https://univ-rennes.hal.science/hal-01578529/file/Doucet%20et%20al.%20-%202016%20-%20Direct%20C3-arylation%20of%202H-indazole%20derivatives%20wit.pdf %L hal-01578529 %U https://univ-rennes.hal.science/hal-01578529 %~ UNIV-RENNES1 %~ CNRS %~ INSA-RENNES %~ ENSC-RENNES %~ ISCR %~ SCR_OMC2012 %~ ISCR-OMC %~ STATS-UR1 %~ UR1-SPM %~ INC-CNRS %~ UR1-UFR-SPM %~ UR1-HAL %~ UR1-SDLM %~ TEST-UNIV-RENNES %~ TEST-UR-CSS %~ UNIV-RENNES %~ INSA-GROUPE %~ TEST-HALCNRS %~ UR1-MMS %~ TEST2-HALCNRS