%0 Journal Article %T Early-onset neonatal sepsis is associated with a high heart rate during automatically selected stationary periods %+ Laboratoire Traitement du Signal et de l'Image (LTSI) %+ Service de Gynécologie et Obstétrique [Rennes] = Gynaecology [Rennes] %+ Vietnam National University [Hanoï] (VNU) %+ Département de Pédiatrie %+ Centre d'Investigation Clinique [Rennes] (CIC) %A Nguyen, Nga %A Vandenbroucke, Laurent %A Hernandez, Alfredo %A Pham, Tu %A Beuchee, Alain %A Pladys, Patrick %Z Institut de la Mère et de L'enfant %Z University of Hanoi, Vietnam %< avec comité de lecture %@ 0803-5253 %J Acta Paediatrica %I Wiley %V 106 %N 5 %P 749-754 %8 2017-05 %D 2017 %R 10.1111/apa.13782 %M 28196284 %K newborn infant %K neonatal sepsis %K Heart Rate %K Heart rate variability %K Signal Processing %Z Life Sciences [q-bio]/Human health and pathology/Pediatrics %Z Life Sciences [q-bio]/Human health and pathology/Infectious diseases %Z Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system %Z Engineering Sciences [physics]/Signal and Image processingJournal articles %X AIM: This study examined the heart rate variability characteristics associated with early-onset neonatal sepsis in a prospective, observational controlled study.METHODS: Eligible patients were full-term neonates hospitalised with clinical signs that suggested early-onset sepsis and a C-reactive protein of >10 mg/L. Sepsis was considered proven in cases of symptomatic septicaemia, meningitis, pneumonia or enterocolitis. Heart rate variability parameters (n = 16) were assessed from five-, 15- and 30-minute stationary sequences automatically selected from electrocardiographic recordings performed at admission and compared with a control group using the U-test with post hoc Benjamini-Yekutieli correction. Stationary sequences corresponded to the periods with the lowest changes of heart rate variability over time.RESULTS: A total of 40 full-term infants were enrolled, including 14 with proven sepsis. The mean duration of the cardiac cycle length was lower in the proven sepsis group than in the control group (n = 11), without other significant changes in heart rate variability parameters. These durations, measured in five-minute stationary periods, were 406 (367-433) ms in proven sepsis group versus 507 (463-522) ms in the control group (p < 0.05).CONCLUSION: Early-onset neonatal sepsis was associated with a high mean heart rate measured during automatically selected stationary periods. %G English %2 https://univ-rennes.hal.science/hal-01518407/document %2 https://univ-rennes.hal.science/hal-01518407/file/Nguyen%20et%20al.%20-%202017%20-%20Early%20onset%20neonatal%20sepsis%20is%20associated%20with%20a%20h.pdf %L hal-01518407 %U https://univ-rennes.hal.science/hal-01518407 %~ INSERM %~ UNIV-RENNES1 %~ LTSI %~ CARDIO %~ HL %~ CIC %~ CIC203 %~ STATS-UR1 %~ UR1-UFR-SVE %~ UR1-HAL %~ UR1-MATH-STIC %~ UR1-SDV %~ TEST-UNIV-RENNES %~ TEST-UR-CSS %~ UNIV-RENNES %~ UR1-MATH-NUM %~ UR1-BIO-SA