%0 Journal Article %T New erythritol derivatives from the fertile form of Roccella montagnei %+ Ho Chi Minh City University of Pedagogy %+ Ecole des Sciences Naturelles Ho Chi Minh Ville %+ Chulalongkorn University [Bangkok] %+ Institut des Sciences Chimiques de Rennes (ISCR) %+ University of Medicine and Pharmacy (VIETNAM) %+ Roskilde University %+ Institut d'Électronique et des Technologies du numéRique (IETR) %+ Life Sciences dpt. - Genomics & Microbial Biodiversity div. %A Duong, Thuc Huy %A Huynh, Bui Linh Chi %A Chavasiri, Warinthorn %A Chollet-Krugler, Marylene %A Nguyen, van Kieu %A Nguyen, Thi Hoai Thu %A Hansen, Poul Erik %A Le Pogam, Pierre %A Thüs, Holger %A Boustie, Joël %A Nguyen, Kim Phi Phung %Z This research was supported by Vietnam's National Foundation for Science and Technology Development (NAFOSTED) grant #104.01–2013.17. This work was also supported partly by University of Rennes 1 (ED SDLM) through a scholarship for T. H. Duong from January to April 2016. %< avec comité de lecture %@ 0031-9422 %J Phytochemistry %I Elsevier %V 137 %P 156-164 %8 2017-05 %D 2017 %R 10.1016/j.phytochem.2017.02.012 %M 28222890 %K cytotoxicity %K Lichen %K Montagnetol %K Montagnetol derivatives %K Roccella montagnei (fertile form) %K Stereochemistry %Z Chemical SciencesJournal articles %X Chemical investigation of the methanol extract of the fertile form of Roccella montagnei collected in Vietnam afforded twelve secondary metabolites, including five new montagnetol derivatives, orsellinylmontagnetols A-D and a furanyl derivative together with seven known compounds. Their chemical structures were elucidated by analysis of 1D and 2D NMR and high resolution mass spectroscopic data. The relative stereochemistry of two chiral centers (C-2 and C-3) of orsellinylmontagnetols A and B was elucidated by comparison of their coupling constants and the specific rotation with those reported in the literature while the absolute stereochemistry was determined by the application of a modified Mosher method for the hydroxy group at C-3. The absolute configuration (2R,3S) of the butanetetraol moiety of these compounds is in accordance with that of erythrin, a recognized chemotaxonomic marker of the genus Roccella. Five of these compounds were evaluated for their cytotoxic activities against four cancer cell lines. Only orsellinylmontagnetol A exerted a moderate activity against MCF-7 cell line with an IC50 value of 68.39 ± 3.46 μM. %G English %2 https://univ-rennes.hal.science/hal-01501264/document %2 https://univ-rennes.hal.science/hal-01501264/file/New%20erythritol%20derivatives_accepted.pdf %L hal-01501264 %U https://univ-rennes.hal.science/hal-01501264 %~ UNIV-NANTES %~ UNIV-RENNES1 %~ CNRS %~ INSA-RENNES %~ ENSC-RENNES %~ IETR %~ ISCR %~ SCR-PNSCM %~ STATS-UR1 %~ CENTRALESUPELEC %~ UR1-SPM %~ INC-CNRS %~ UR1-UFR-SPM %~ UR1-HAL %~ ISCR-CORINT %~ UR1-MATH-STIC %~ UR1-SDLM %~ UR1-UFR-ISTIC %~ TEST-UNIV-RENNES %~ TEST-UR-CSS %~ UNIV-RENNES %~ INSA-GROUPE %~ ISCR-CORINT1 %~ TEST-HALCNRS %~ UR1-MATH-NUM %~ UR1-MMS %~ ISCR-CORINT3 %~ NANTES-UNIVERSITE %~ UNIV-NANTES-AV2022 %~ TEST2-HALCNRS %~ TEST3-HALCNRS