Maternal and post-weaning scFOS supplementation modulates metabolism and intestinal immunity in adults fed a high-fat diet - Université de Rennes Accéder directement au contenu
Communication Dans Un Congrès Année : 2014

Maternal and post-weaning scFOS supplementation modulates metabolism and intestinal immunity in adults fed a high-fat diet

Résumé

Prebiotic fibres have positive effects on homeostatic systems (glucose metabolism, immunity) and reduce development of high fat diet-related disorders. Our study aimed at evaluating effects of early scFOS consumption on later adult metabolic and immunologic status.Sows received a standard diet supplemented with scFOS (Profeed®, FOS) or not (CTRL) for the last 4 weeks of gestation and the lactation. At postnatal day (PND) 28, 10 piglets were weaned on a CTRL or a FOS diet until PND77. Then they were all fed a standard diet until PND180 and a high-fat (HF) diet until PND270. Glucose tolerance was assessed in vivo at PND264 (IVGTT) while the other metabolic parameters were measured on tissues and plasma sampled at sacrifice (PND270). Intestinal immune responses were assayed in vitro using ileal explants with or without the Peyer’s patch (PP) cultured with ConA or LPS stimuli.Growth, food intake and adiposity were not different between groups during HF diet. Insulin response to a glucose challenge was slightly higher in FOS group, but no other metabolic parameters (basal glycaemia and insulinemia, pancreatic insulin content, gut and plasma GLP-1) were modified. Reduced pro-inflammatory IFNγ and TNFα secretion by ConA-stimulated explants of ileal PP and increased IL-10 secretion by LPS-stimulated ileal explants in FOS group revealed a beneficial effect of early scFOS supplementation on local immunity orientation.Early prebiotic supplementation impacted both the metabolism and adaptive responses of intestinal immunity in adults facing an adverse nutritional environment. This could involve modulation of gut colonization by prebiotics.
Fichier non déposé

Dates et versions

hal-01416003 , version 1 (13-12-2016)

Identifiants

  • HAL Id : hal-01416003 , version 1
  • PRODINRA : 371013

Citer

Cindy Le Bourgot, Sophie Blat, Stéphanie Ferret-Bernard, Laurence Le Normand, Armelle Cahu, et al.. Maternal and post-weaning scFOS supplementation modulates metabolism and intestinal immunity in adults fed a high-fat diet. Rowett-Inra Symposium - 2014 Isapp meeting. Gut Microbiology, from sequence to function, Jun 2014, Aberdeen, United Kingdom. ⟨hal-01416003⟩
64 Consultations
0 Téléchargements

Partager

Gmail Facebook X LinkedIn More