%0 Journal Article %T Impact of ischaemia time on renal function after partial nephrectomy: a systematic review %+ Service d'Urologie [CHU Pitié-Salpêtrière] %+ Service d'urologie [Rennes] = Urology [Rennes] %+ Institut de Génétique et Développement de Rennes (IGDR) %+ Service d'urologie [Mondor] %+ Institut Mondor de Recherche Biomédicale (IMRB) %+ Laboratoire Traitement du Signal et de l'Image (LTSI) %+ Service d'Urologie [CHU Tenon] %+ Service d'Oncologie médicale [CHU Pitié-Salpêtrière] %A Rod, Xavier %A Peyronnet, Benoit %A Seisen, Thomas %A Pradère, Benjamin %A Gomez, Florie D. %A Verhoest, Grégory %A Vaessen, Christophe %A de La Taille, Alexandre %A Bensalah, Karim %A Roupret, Morgan %< avec comité de lecture %@ 1464-4096 %J BJU International %I Wiley %V 118 %N 5 %P 691--704 %8 2016 %D 2016 %R 10.1111/bju.13580 %M 27409986 %K laparoscopic partial nephrectomy %K assisted partial nephrectomy %K invasive partial nephrectomy %K nephron sparing surgery %K warm ischemia %K cell carcinoma %K radical nephrectomy %K oncologic outcomes %K tumor enucleation %K solitary kidney %Z Life Sciences [q-bio]Journal articles %X Objective To assess the impact of ischaemia on renal function after partial nephrectomy (PN). Materials and methods A literature review was performed according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) criteria. In January 2015, the Medline and Embase databases were systematically searched using the protocol ('warm ischemia'[mesh] OR 'warm ischemia'[ti]) AND ('nephrectomy'[mesh] OR 'partial nephrectomy'[ti]). An updated search was performed in December 2015. Only studies based on a solitary kidney model or on a two-kidney model but with assessment of split renal function were included in this review. Results Of the 1119 studies identified, 969 abstracts were screened after duplicates were removed: 29 articles were finally included in this review, including nine studies that focused on patients with a solitary kidney. None of the nine studies adjusting for the amount of preserved parenchyma found a negative impact of warm ischaemia time on postoperative renal function, unless this was extended beyond a 25-min threshold. The quality and the quantity of preserved parenchyma appeared to be the main contributors to postoperative renal function. Conclusion Currently, no evidence supports that limited ischaemia time (i.e. <= 25 min) has a higher risk of reducing renal function after PN compared to a 'zero ischaemia' technique. Several recent studies have suggested that prolonged warm ischaemia (>25-30 min) could cause an irreversible ischaemic insult to the surgically treated kidney. %G English %L hal-01414467 %U https://univ-rennes.hal.science/hal-01414467 %~ UNIV-RENNES1 %~ CNRS %~ LTSI %~ APHP %~ IFR140 %~ IMRB %~ UPEC %~ HL %~ STATS-UR1 %~ UR1-HAL %~ UR1-MATH-STIC %~ TEST-UNIV-RENNES %~ TEST-UR-CSS %~ UNIV-RENNES %~ SORBONNE-UNIVERSITE %~ SU-INF-2018 %~ SU-MEDECINE %~ SU-MED %~ UR1-MATH-NUM %~ UR1-BIO-SA %~ ALLIANCE-SU