%0 Journal Article %T High-Fat Diet-Induced IL-17A Exacerbates Psoriasiform Dermatitis in a Mouse Model of Steatohepatitis %+ Laboratoire Inflammation, Tissus épithéliaux et Cytokines (LITEC) %+ Signalisation et Transports Ioniques Membranaires (STIM) %+ Laboratoire d'Anatomo-Pathologie %+ Institut de recherche en santé, environnement et travail (Irset) %+ Centre d'Immunologie et de Maladies Infectieuses (CIMI) %+ Hôpital de la Milétrie %A Vasseur, Philippe %A Serres, Laura %A Jegou, Jean-Francois %A Pohin, Mathilde %A Delwail, Adriana %A Petit-Paris, Isabelle %A Levillain, Pierre %A Favot, Laure %A Samson, Michel %A Yssel, Hans %A Morel, Franck %A Silvain, Christine %A Lecron, Jean-Claude %Z University of Poitiers %Z Poitiers University Hospital %Z Nord Deux-Sevres Hospital %Z Region Poitou-Charentes %< avec comité de lecture %@ 0002-9440 %J American Journal of Pathology %I American Society for Investigative Pathology / Elsevier %V 186 %N 9 %P 2292--2301 %8 2016 %D 2016 %R 10.1016/j.ajpath.2016.05.012 %M 27423696 %K innate lymphoid-cells %K liver-disease %K skin inflammation %K risk %K mice %K cytokines %K il-22 %Z Life Sciences [q-bio]/Ecology, environment/HealthJournal articles %X Recent studies suggest that psoriasis may be more severe in patients with nonalcoholic fatty liver disease, particularly in those with the inflammatory stage of steatohepatitis [nonalcoholic steatohepatitis (NASH)]. Herein, we investigated the impact of diet-induced steatohepatitis on the severity of imiquimod-induced psoriasiform dermatitis. Mice fed with a high-fat diet developed steatohepatitis reminiscent of human NASH with ballooning hepatocytes and significant liver fibrosis. Mice with steatohepatitis also displayed moderate cutaneous inflammation characterized by erythema, dermalinfiltrates of CD45(+) leukocytes, and a local production of IL-17A. Moreover, steatohepatitis was associated with an epidermal activation of caspase-1 and cutaneous overexpression of IL-1 beta. Imiquimod-induced psoriasiform dermatitis was exacerbated in mice with steatohepatitis as compared to animals fed with a standard diet. Scale formation and acanthosis were aggravated, in correlation with increased IL-17A and IL-22 expression in inflamed skins. Finally, intradermal injection of IL-17A in standard diet-fed mice recapitulated the cutaneous pathology of mice with steatohepatitis. The results show that high-fat diet induced steatohepatitis aggravates the inflammation in psoriasiform dermatitis, via the cutaneous production of IL-17A. In agreement with clinical data, this description of a novel extrahepatic manifestation of NASH should sensitize dermatologists to the screening and the management of fatty liver in psoriatic patients. %G English %L hal-01390977 %U https://univ-rennes.hal.science/hal-01390977 %~ UPMC %~ UNIV-RENNES1 %~ UNIV-TOURS %~ CNRS %~ UNIV-ANGERS %~ UNIV-POITIERS %~ IFR140 %~ GIP-BE %~ IRSET %~ CIMI %~ STATS-UR1 %~ IRSET-SMS %~ IRSET-CCII %~ IRSET-TREC %~ IRSET-HIAEC %~ IRSET-SMLF %~ IRSET-ERD %~ IRSET-VCER %~ IRSET-NEED %~ IRSET-TNGC %~ UR1-UFR-SVE %~ UR1-HAL %~ UR1-SDV %~ IRSET-2 %~ UPMC_POLE_4 %~ LITEC %~ TEST-UNIV-RENNES %~ TEST-UR-CSS %~ UNIV-RENNES %~ SORBONNE-UNIVERSITE %~ SU-MEDECINE %~ IRSET-2-EX-HIAEC %~ SU-TI %~ UR1-BIO-SA %~ STIM %~ ALLIANCE-SU %~ TEST3-HALCNRS