Multimodal therapy including yttrium-90 radioembolization as a bridging therapy to liver transplantation for a huge and locally advanced intrahepatic cholangiocarcinoma - Université de Rennes Accéder directement au contenu
Article Dans Une Revue Journal of Gastrointestinal and Liver Diseases Année : 2016

Multimodal therapy including yttrium-90 radioembolization as a bridging therapy to liver transplantation for a huge and locally advanced intrahepatic cholangiocarcinoma

Résumé

Treatment of intrahepatic cholangiocarcinoma remains a major challenge. For an unresectable lesion without extrahepatic spread, liver transplantation could be a potential solution but it is still associated with poor oncologic results owing to the absence of effective neoadjuvant treatment. We report the case of a young man with locally advanced intrahepatic cholangiocarcinoma presenting with multiple intrahepatic metastases and vascular structure involvement. The lesion was significantly downstaged by a multimodal therapy including intra-arterial Yttrium-90 radioembolization, systemic chemotherapy and external radiotherapy, allowing liver transplantation. Three years after the procedure, oncologic outcome is excellent with no sign of recurrence. Multimodal therapy including Yttrium-90 radioembolization could be relevant as neoadjuvant treatment before liver transplantation for unresectable intrahepatic cholangiocarcinoma. © 2016, Romanian Society of Gastroenterology. All rights reserved.

Dates et versions

hal-01373302 , version 1 (28-09-2016)

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M. Rayar, G.B. Levi Sandri, P. Houssel-Debry, C. Camus, L. Sulpice, et al.. Multimodal therapy including yttrium-90 radioembolization as a bridging therapy to liver transplantation for a huge and locally advanced intrahepatic cholangiocarcinoma. Journal of Gastrointestinal and Liver Diseases, 2016, 25 (3), pp.401--404. ⟨10.15403/jgld.2014.1121.253.y90⟩. ⟨hal-01373302⟩
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