Review – Lichen-associated bacteria as a hot spot of chemodiversity: focus on uncialamycin, a promising compound for future medicinal applications - Université de Rennes Accéder directement au contenu
Article Dans Une Revue Planta Medica Année : 2016

Review – Lichen-associated bacteria as a hot spot of chemodiversity: focus on uncialamycin, a promising compound for future medicinal applications

Résumé

This review presents the state of knowledge on the medicinal potential of bacteria associated with lichens. In fact, besides the classical symbiotic partners (photobiont and mycobiont) forming the lichen thallus, associated bacteria have been recently described as a third partner. Various studies demonstrated the diversity of these communities with a predominance of Alphaproteobacteria. Bacterial groups more relevant for secondary metabolite synthesis have also been revealed. This article summarizes studies reporting the abilities of these communities to produce metabolites with relevant bioactivities. The biotechnological interest of these bacteria for drug discovery is highlighted regarding the production of compounds with therapeutic potential. Special focus is given to the synthesis of the most promising compound, uncialamycin, a potent enediyne isolated from a Streptomyces sp. associated with Cladonia uncialis.
Fichier principal
Vignette du fichier
ReviewplantamedicanewversionfinalePlantaMed_final-v2.pdf (825.04 Ko) Télécharger le fichier
Origine : Fichiers produits par l'(les) auteur(s)
Loading...

Dates et versions

hal-01360065 , version 1 (09-11-2016)

Identifiants

Citer

Delphine Parrot, Nathalie Legrave, David Delmail, Martin Grube, Marcelino T. Suzuki, et al.. Review – Lichen-associated bacteria as a hot spot of chemodiversity: focus on uncialamycin, a promising compound for future medicinal applications. Planta Medica, 2016, 82 (13), pp.1143-1152. ⟨10.1055/s-0042-105571⟩. ⟨hal-01360065⟩
347 Consultations
235 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More