%0 Journal Article %T Prenatal stress and early-life exposure to fluoxetine have enduring effects on anxiety and hippocampal BDNF gene expression in adult male offspring %+ Maastricht University [Maastricht] %+ Institut de psychiatrie et neurosciences (U894 / UMS 1266) %+ Neurophysiology Unit, GIGA Neurosciences %+ Institut de recherche en santé, environnement et travail (Irset) %+ Donders Institute for Brain, Cognition and Behaviour %+ University of Würzburg = Universität Würzburg %A Boulle, Fabien %A Pawluski, Jodi L. %A Homberg, Judith R. %A Machiels, Barbie %A Kroeze, Yvet %A Kumar, Neha %A Steinbusch, Harry W. M. %A Kenis, Gunter %A Hove, Daniel L. A, van Den %Z JLP was funded by a Charge de Recherche position with Fonds de la Recherche Scientifique (FRS-FNRS). %< avec comité de lecture %@ 0012-1630 %J Developmental Psychobiology %I Wiley %V 58 %N 4 %P 427--438 %8 2016-05 %D 2016 %R 10.1002/dev.21385 %M 26608001 %K BDNF %K depression %K Hippocampus %K Neuroplasticity %K prenatal stress %K SEX DIFFERENCES %K SSRI %K TrkB %Z Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology %Z Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Psychology and behavior %Z Life Sciences [q-bio]/Development Biology/Embryology and OrganogenesisJournal articles %X With the growing use of selective serotonin reuptake inhibitor medications (SSRIs) for the treatment of depression during the perinatal period, questions have been raised about the longterm impact of these medications on development. We aimed to investigate how developmental SSRI exposure may alter affect-related behaviors and associated molecular processes in offspring using a rodent model of maternal stress and depression. For this purpose, prenatally stressed or non-stressed male offspring were exposed to fluoxetine (5 mg/kg/day) or vehicle, via lactation, until weaning. Primary results show that postnatal fluoxetine exposure differentially altered anxiety-like behavior by increasing anxiety in non-stressed offspring and decreasing anxiety in prenatally stressed offspring. In the hippocampus, developmental fluoxetine exposure decreased BDNF IV and TrkB mRNA expression. Prenatal stress alone also decreased escape behaviors and decreased hippocampal BDNF IV mRNA expression. These data provide important evidence for the long-term programming effects of early-life exposure to SSRIs on brain and behavior. %G English %2 https://univ-rennes.hal.science/hal-01305478/document %2 https://univ-rennes.hal.science/hal-01305478/file/Developmental%20SSRIs%2C%20anxiety%20and%20BDNF_accepted.pdf %L hal-01305478 %U https://univ-rennes.hal.science/hal-01305478 %~ INSERM %~ UNIV-PARIS5 %~ UNIV-RENNES1 %~ UNIV-ANGERS %~ IFR140 %~ IRSET %~ STATS-UR1 %~ IRSET-SMS %~ IRSET-CCII %~ IRSET-TREC %~ IRSET-HIAEC %~ IRSET-SMLF %~ IRSET-ERD %~ IRSET-VCER %~ IRSET-NEED %~ IRSET-TNGC %~ UR1-UFR-SVE %~ UR1-HAL %~ USPC %~ UR1-SDV %~ TEST-UNIV-RENNES %~ TEST-UR-CSS %~ UNIV-RENNES %~ UNIV-PARIS %~ UP-SANTE %~ UR1-BIO-SA