Safety and feasibility of laparoscopic nephrectomy for big tumors (•10 cm): a retrospective multicentric study - Université de Rennes Accéder directement au contenu
Article Dans Une Revue Clinical Genitourinary Cancer Année : 2016

Safety and feasibility of laparoscopic nephrectomy for big tumors (•10 cm): a retrospective multicentric study

Pierre Bigot
  • Fonction : Auteur
Burak Turna
  • Fonction : Auteur
Julien Berger

Résumé

Objective - Evaluate the feasibility of laparoscopic nephrectomy for big tumors. Material and methods - Data from 116 patients were retrospectively collected from 16 tertiary centres. Clinical and operative parameters, tumor characteristics, pre- and postoperative parameters, and renal function before and after surgery were analyzed. Results - Mean age and body mass index were 61 years and 27.8 kg/m(2), respectively. Males represented 63.8% of patients, and 54.4% presented symptoms at diagnosis. Median tumor size was 11 cm, and 75% of the cases were performed by expert surgeons. Median operative time and blood loss were 180 minutes and 200 mL respectively. Conversion to open surgery was necessary in 20.7% of cases. Intraoperative complications related to massive hemorrhage occurred in 16.4% of patients, resulting in open conversion in 62.5%. Major postoperative complications occurred in only 10 patients (8.6%). In univariate analysis, intraoperative complications, age, and blood loss were predictive factors of conversion to open surgery. Positive surgical margins occurred in 6 patients (5.2%). None of them presented a local recurrence. Predictive factors of recurrence or progression were lymph node invasion, metastases, and Furhman grade. Conclusion - Laparoscopic nephrectomy for tumors > 10 cm can be performed safely. Complication rate and positive surgical margins are similar to open surgery. In experienced hands, the benefit of a mini invasive surgery remains evident.
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Dates et versions

hal-01267294 , version 1 (04-02-2016)

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Grégory Verhoest, Jean-Philippe Couapel, Emmanuel Oger, Nathalie Rioux-Leclercq, Géraldine Pignot, et al.. Safety and feasibility of laparoscopic nephrectomy for big tumors (•10 cm): a retrospective multicentric study. Clinical Genitourinary Cancer, 2016, 14 (4), pp.e335-e340. ⟨10.1016/j.clgc.2016.01.007⟩. ⟨hal-01267294⟩
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