%0 Journal Article %T Gene expression profiling of the tumor microenvironment in human intrahepatic cholangiocarcinoma %+ Service de Chirurgie Hépatobiliaire et Digestive [Rennes] = Hepatobiliary and Digestive Surgery [Rennes] %+ Foie, métabolismes et cancer %+ CHU Pontchaillou [Rennes] %+ Centre d'Investigation Clinique [Rennes] (CIC) %+ Service d'anatomie et cytologie pathologiques [Rennes] = Anatomy and Cytopathology [Rennes] %A Sulpice, Laurent %A Desille, Mireille %A Turlin, Bruno %A Fautrel, Alain %A Boudjema, Karim %A Clément, Bruno %A Coulouarn, Cédric %Z The authors thank Biosit and Biogenouest for access to Plateforme Génomique Santé, Centre de Ressources Biologiques Santé, and H2P2 histopathological platform. This work was supported by Grants from Inserm, Université de Rennes 1, Institut National du Cancer (Cancéropoles IDF & GO), Ligue contre le cancer and Novartis Oncology. %< avec comité de lecture %@ 2213-5960 %J Genomics Data %I Elsevier %V 7 %P 229–232 %8 2016-03 %D 2016 %R 10.1016/j.gdata.2016.01.012 %M 26981414 %K Profiling %K Liver %K Microenvironment %K Cancer %K Cholangiocarcinoma %Z Life Sciences [q-bio]/GeneticsJournal articles %X Intrahepatic cholangiocarcinoma (ICC) is the second most common type of malignant primary tumors in the liver. ICC is an aggressive cancer with a poor survival and limited therapeutic options. At the histological level, ICC is characterized by an abundant stroma (i.e. the tumor microenvironment that notably includes components of the extracellular matrix, stromal cells and soluble factors). Tumor microenvironment is known to play a key role in tumor onset and progression but it is poorly characterized at the molecular level. Thus, this study was specifically designed to identify genes that are significantly deregulated in the tumor microenvironment of human ICC. Here we provide a detailed description of the experimental design and methods used to acquire the genomic data deposited into Gene Expression Omnibus (GEO) under the accession number GSE45001. Our genomic dataset provides insights on the molecular pathways altered in the microenvironment of ICC and allows the identification of novel ICC biomarkers, as exemplified previously in Hepatology (PMID: 23775819) %G English %2 https://univ-rennes.hal.science/hal-01259227/document %2 https://univ-rennes.hal.science/hal-01259227/file/Gene%20expression%20profiling%20of%20the%20tumor%20microenvironment%20-%20version%20of%20record.pdf %L hal-01259227 %U https://univ-rennes.hal.science/hal-01259227 %~ INSERM %~ UNIV-RENNES1 %~ IFR140 %~ HL %~ CIC %~ CIC203 %~ U991 %~ U991-E1 %~ U991-E2 %~ U991-E3 %~ U991-E4 %~ STATS-UR1 %~ NUMECAN %~ NUMECAN-CIMIAD %~ NUMECAN-EXPRES %~ NUMECAN-TGTC %~ UR1-UFR-SVE %~ UR1-HAL %~ UR1-SDV %~ CRBS %~ TEST-UNIV-RENNES %~ TEST-UR-CSS %~ UNIV-RENNES %~ NUMECAN-METHER %~ UR1-BIO-SA